Protoporphyrin IX/Cobyrinate Derived Hybrids - Novel Activators of Soluble Guanylyl Cyclase

被引：9

作者：

Chrominski, Mikolaj ^{[1
]}

Proinsias, Keith O. ^{[1
]}

Martin, Emil ^{[2
]}

Gryko, Dorota ^{[1
]}

机构：

[1] Polish Acad Sci, Inst Organ Chem, PL-01224 Warsaw, Poland

[2] Univ Texas Houston, Univ Texas Hlth Sci Ctr Houston, Div Cardiol, Dept Internal Med, Houston, TX 77054 USA

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2013年 / 2013卷 / 08期

基金：

美国国家卫生研究院;

关键词：

Cobalamines; Cooperative effects; Porphyrinoids; Structure-activity relationships; Click chemistry; HYDROPHOBIC VITAMIN-B-12 DERIVATIVES; NITRIC-OXIDE; HEME; CYCLOADDITION; PORPHYRINS; DISCOVERY; POSITION; LIGANDS; BINDING; MOIETY;

D O I：

10.1002/ejoc.201201303

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Cobyrinate/protoporphyrin IX molecular hybrids were prepared through application of the CuOAc catalyzed azide-alkyne cycloaddition (CuAAC) "click" reaction. The synthesis involved selective preparation of cobyrinate and PpIX derived building blocks possessing respectively terminal alkyne and azide moieties, followed by a CuOAc catalyzed cycloaddition reaction. Synthesized molecules activated soluble guanylyl cyclase and showed strong linker-length/activation dependence.

引用

页码：1530 / 1537

页数：8

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