Olfactory Pathology in Central Nervous System Demyelinating Diseases

被引:42
作者
DeLuca, Gabriele C. [1 ]
Joseph, Albert [3 ]
George, Jithin [1 ]
Yates, Richard L. [1 ]
Hamard, Marie [1 ]
Hofer, Monika [2 ]
Esiri, Margaret M. [1 ]
机构
[1] Univ Oxford, Nuffield Dept Clin Neurosci, Oxford, England
[2] Univ Oxford, Nuffield Dept Clin Lab Sci, Oxford, England
[3] Univ Oxford, Oxford Med Sch, Oxford, England
基金
英国医学研究理事会;
关键词
demyelinating disease; multiple sclerosis; neuroinflammation; olfaction; pathology; MULTIPLE-SCLEROSIS EVIDENCE; NEUROMYELITIS-OPTICA; AXONAL LOSS; DYSFUNCTION;
D O I
10.1111/bpa.12209
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Olfactory dysfunction is common in multiple sclerosis (MS). Olfactory bulb and tract pathology in MS and other demyelinating diseases remain unexplored. A human autopsy cohort of pathologically confirmed cases encompassing the spectrum of demyelinating disease (MS; n = 17), neuromyelitis optica [(NMO); n = 3] and acute disseminated encephalomyelitis [(ADEM); n = 7] was compared to neuroinflammatory [herpes simplex virus encephalitis (HSE); n = 3], neurodegenerative [Alzheimer's disease (AD); n = 4] and non-neurologic (n = 8) controls. For each case, olfactory bulbs and/or tracts were stained for myelin, axons and inflammation. Inferior frontal cortex and hippocampus were stained for myelin in a subset of MS and ADEM cases. Olfactory bulb/tract demyelination was frequent in all demyelinating diseases [MS 12/17 (70.6%); ADEM 3/7 (42.9%); NMO 2/3 (66.7%)] but was absent in HSE, AD and non-neurologic controls. Inflammation was greater in the demyelinating diseases compared to non-neurologic controls. Olfactory bulb/tract axonal loss was most severe in MS where it correlated significantly with the extent of demyelination (r = 0.610, P = 0.009) and parenchymal inflammation (r = 0.681, P = 0.003). The extent of olfactory bulb/tract demyelination correlated with that found in the adjacent inferior frontal cortex but not hippocampus. We provide unequivocal evidence that olfactory bulb/tract demyelination is frequent, can occur early and is highly inflammatory, and is specific to demyelinating disease.
引用
收藏
页码:543 / 551
页数:9
相关论文
共 35 条
[1]  
Carswell R., 1838, PATHOLOGICAL ANATOMY
[2]  
Charcot J.-M., 1868, HISTOLOGIE SCLEROSE
[3]  
Cruveilhier J, 1835, ANATOMIE PATHOLOGIQU, P1835
[4]  
Dawson JW., 1916, Edinb. Med. J, V17, P229
[5]   The contribution of demyelination to axonal loss in multiple sclerosis [J].
DeLuca, G. C. ;
Williams, K. ;
Evangelou, N. ;
Ebers, G. C. ;
Esiri, M. M. .
BRAIN, 2006, 129 :1507-1516
[6]   Casting light on multiple sclerosis heterogeneity: the role of HLA-DRB1 on spinal cord pathology [J].
DeLuca, Gabriele C. ;
Alterman, Rose ;
Martin, Jenny L. ;
Mittal, Arunesh ;
Blundell, Samkeliso ;
Bird, Shannon ;
Beale, Harry ;
San Hong, Lai ;
Esiri, Margaret M. .
BRAIN, 2013, 136 :1025-1034
[7]   Axonal loss in multiple sclerosis: a pathological survey of the corticospinal and sensory tracts [J].
DeLuca, GC ;
Ebers, GC ;
Esiri, MM .
BRAIN, 2004, 127 :1009-1018
[8]   Olfaction and neurological diseases: a review of the literature. [J].
Demarquay, G. ;
Ryviln, P. ;
Royet, J. P. .
REVUE NEUROLOGIQUE, 2007, 163 (02) :155-167
[9]   Protein co-expression with axonal injury in multiple sclerosis plaques [J].
Diaz-Sanchez, M ;
Williams, K ;
DeLuca, GC ;
Esiri, MM .
ACTA NEUROPATHOLOGICA, 2006, 111 (04) :289-299
[10]   The olfactory vector hypothesis of neurodegenerative disease: Is it viable? [J].
Doty, Richard L. .
ANNALS OF NEUROLOGY, 2008, 63 (01) :7-15