A Repressor Protein Complex Regulates Leaf Growth in Arabidopsis

被引：102

作者：

Gonzalez, Nathalie ^{[1
,2
]}

Pauwels, Laurens ^{[1
,2
]}

Baekelandt, Alexandra ^{[1
,2
]}

De Milde, Liesbeth ^{[1
,2
]}

Van Leene, Jelle ^{[1
,2
]}

Besbrugge, Nienke ^{[1
,2
]}

Heyndrickx, Ken S. ^{[1
,2
]}

Perez, Amparo Cuellar ^{[1
,2
]}

Durand, Astrid Nagels ^{[1
,2
]}

De Clercq, Rebecca ^{[1
,2
]}

Van De Slijke, Eveline ^{[1
,2
]}

Bossche, Robin Vanden ^{[1
,2
]}

Eeckhout, Dominique ^{[1
,2
]}

Gevaert, Kris ^{[3
,4
]}

Vandepoele, Klaas ^{[1
,2
]}

De Jaeger, Geert ^{[1
,2
]}

Goossens, Alain ^{[1
,2
]}

Inze, Dirk ^{[1
,2
]}

机构：

[1] Univ Ghent VIB, Dept Plant Syst Biol, B-9052 Ghent, Belgium

[2] Univ Ghent, Dept Plant Biotechnol & Bioinformat, B-9052 Ghent, Belgium

[3] Univ Ghent VIB, Dept Med Prot Res & Biochem, B-9000 Ghent, Belgium

[4] Univ Ghent, Dept Biochem, B-9000 Ghent, Belgium

来源：

PLANT CELL | 2015年 / 27卷 / 08期

关键词：

ASYMMETRIC CELL-DIVISION; GENOME-WIDE ANALYSIS; STOMATAL DEVELOPMENT; KIX DOMAIN; TRANSCRIPTION FACTORS; SPLICE VARIANT; JAZ PROTEINS; CHIP-SEQ; THALIANA; GENES;

D O I：

10.1105/tpc.15.00006

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cell number is an important determinant of final organ size. In the leaf, a large proportion of cells are derived from the stomatal lineage. Meristemoids, which are stem cell-like precursor cells, undergo asymmetric divisions, generating several pavement cells adjacent to the two guard cells. However, the mechanism controlling the asymmetric divisions of these stem cells prior to differentiation is not well understood. Here, we characterized PEAPOD (PPD) proteins, the only transcriptional regulators known to negatively regulate meristemoid division. PPD proteins interact with KIX8 and KIX9, which act as adaptor proteins for the corepressor TOPLESS. D3-type cyclin encoding genes were identified among direct targets of PPD2, being negatively regulated by PPDs and KIX8/9. Accordingly, kix8 kix9 mutants phenocopied PPD loss-of-function producing larger leaves resulting from increased meristemoid amplifying divisions. The identified conserved complex might be specific for leaf growth in the second dimension, since it is not present in Poaceae (grasses), which also lack the developmental program it controls.

引用

页码：2273 / 2287

页数：15

共 63 条

[1] Exit from Proliferation during Leaf Development in Arabidopsis thaliana: A Not-So-Gradual Process [J].