Survival Following Tumor Recurrence in Children With Medulloblastoma

被引：50

作者：

Johnston, Donna L. ^{[1
]}

Keene, Daniel ^{[2
]}

Strother, Douglas ^{[7
]}

Taneva, Maria ^{[1
]}

Lafay-Cousin, Lucie ^{[7
]}

Fryer, Chris ^{[9
]}

Scheinemann, Katrin ^{[3
]}

Carret, Anne-Sophie ^{[10
]}

Fleming, Adam ^{[11
]}

Afzal, Samina ^{[14
]}

Wilson, Beverly ^{[8
]}

Bowes, Lynette ^{[15
]}

Zelcer, Shayna ^{[4
]}

Mpofu, Chris ^{[16
]}

Silva, Mariana ^{[5
]}

Larouche, Valerie ^{[12
]}

Brossard, Josee ^{[13
]}

Bouffet, Eric ^{[6
]}

机构：

[1] Childrens Hosp Eastern Ontario, Div Pediat Hematol Oncol, 401 Smyth Rd, Ottawa, ON K1H 8L1, Canada

[2] Childrens Hosp Eastern Ontario, Div Pediat Neurol, Ottawa, ON, Canada

[3] McMaster Childrens Hosp, Div Pediat Hematol Oncol, Hamilton, ON, Canada

[4] Childrens Hosp Western Ontario, Div Pediat Hematol Oncol, London, ON, Canada

[5] Kingston Gen Hosp, Div Pediat Hematol Oncol, Kingston, ON, Canada

[6] Hosp Sick Children, Div Pediat Hematol Oncol, Toronto, ON, Canada

[7] Univ Calgary, Sect Pediat Oncol & Blood & Marrow Transplantat, Calgary, AB, Canada

[8] Stollery Childrens Hosp, Div Pediat Hematol Oncol, Edmonton, AB, Canada

[9] British Columbia Childrens Hosp, Div Pediat Hematol Oncol, Vancouver, BC, Canada

[10] St Justine Hosp, Div Pediat Hematol Oncol, Montreal, PQ, Canada

[11] Montreal Childrens Hosp, Div Pediat Hematol Oncol, Montreal, PQ, Canada

[12] Ctr Hosp Univ Quebec, Div Pediat Hematol Oncol, Quebec City, PQ, Canada

[13] CHU Sherbrooke, Div Pediat Hematol Oncol, Sherbrooke, PQ, Canada

[14] IWK Childrens Hosp, Div Pediat Hematol Oncol, Halifax, NS, Canada

[15] Janeway Childrens Hosp, Div Pediat Hematol Oncol, St John, NF, Canada

[16] Saskatoon Childrens Hosp, Div Pediat Hematol Oncol, Saskatoon, SK, Canada

来源：

JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY | 2018年 / 40卷 / 03期

关键词：

medulloblastoma; recurrence; pediatric; HIGH-DOSE CHEMOTHERAPY; NERVOUS-SYSTEM TUMORS; RELAPSE PATTERNS; BRAIN;

D O I：

10.1097/MPH.0000000000001095

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Medulloblastoma is the most common malignant brain tumor in children. Published survival rates for this tumor are approximate to 70%; however, there is limited published information on outcome after disease recurrence. This was an observational study which included all persons under the age of 18 years diagnosed with medulloblastoma from 1990 to 2009 inclusive in Canada. Data collected included date of diagnosis, age at diagnosis, sex, stage, pathology, treatment, recurrence, and current status. Survival rates were determined. In total, 550 cases were ascertained meeting the study criteria. The overall survival rate at 1 year was 83.6%+/- 1.7%, at 3 years 77.2%+/- 1.9%, and at 5 years 72.5%+/- 20%. The progression-free survival rates were 78%+/- 1.9%, 70%+/- 2.1%, and 69 +/- 2.1% at 1, 3, and 5 years from initial diagnosis. In total, 173 (31.2%) were reported to have had tumor recurrence and 23 (11.4%) of them were alive at the time of survey with an overall survival rate at 1 year of 38.3%+/- 4%, at 2 years of 16.9%+/- 3.3%, and at 5 years of 12.4%+/- 2.8%. Our data confirm that children with recurrent medulloblastoma have a poor prognosis, supporting the need for novel treatment approaches for this group.

引用

页码：E159 / E163

页数：5

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