Intermittent Fasting Modulation of the Diabetic Syndrome in Streptozotocin-Injected Rats

被引：46

作者：

Belkacemi, Louiza ^{[3
]}

Selselet-Attou, Ghalem ^{[3
]}

Hupkens, Emeline ^{[1
]}

Nguidjoe, Evrard ^{[2
]}

Louchami, Karim ^{[1
]}

Sener, Abdullah ^{[1
]}

Malaisse, Willy J. ^{[1
]}

机构：

[1] Univ Libre Bruxelles, Lab Expt Hormonol, B-1070 Brussels, Belgium

[2] Univ Libre Bruxelles, Pharmacol Lab, B-1070 Brussels, Belgium

[3] Univ Mostaganem, Lab Technol Alimentaire & Nutr, Mostaganem 1070, Algeria

来源：

INTERNATIONAL JOURNAL OF ENDOCRINOLOGY | 2012年 / 2012卷

关键词：

ENERGY RESTRICTION; INSULIN ACTION; SHORT-TERM; ALPHA; MOUSE; INDIVIDUALS; ISLETS; CELLS; MODEL;

D O I：

10.1155/2012/962012

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

This study investigates the effects of intermittent overnight fasting in streptozotocin-induced diabetic rats (STZ rats). Over 30 days, groups of 5-6 control or STZ rats were allowed free food access, starved overnight, or exposed to a restricted food supply comparable to that ingested by the intermittently fasting animals. Intermittent fasting improved glucose tolerance, increased plasma insulin, and lowered Homeostatis Model Assessment index. Caloric restriction failed to cause such beneficial effects. The beta-cell mass, as well as individual beta-cell and islet area, was higher in intermittently fasting than in nonfasting STZ rats, whilst the percentage of apoptotic beta-cells appeared lower in the former than latter STZ rats. In the calorie-restricted STZ rats, comparable findings were restricted to individual islet area and percentage of apoptotic cells. Hence, it is proposed that intermittent fasting could represent a possible approach to prevent or minimize disturbances of glucose homeostasis in human subjects.

引用

页数：12

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