Evaluation of poly(hydroxyethyl acrylate/itaconic acid) hydrogels for controlled delivery of transition metal complexes with Oxaprozin as potential antiproliferative agents

被引：13
作者：
Babic, Marija M. [1 ]
Bozic, Bojan D. [1 ]
Bozic, Biljana D. [2 ]
Filipovic, Jovanka M. [1 ]
Uscumlic, Gordana S. [1 ]
Tomic, Simonida Lj. [1 ]
机构：
[1] Univ Belgrade, Fac Technol & Met, Belgrade 11000, Serbia
[2] Univ Belgrade, Fac Biol, Belgrade, Serbia
来源：
JOURNAL OF MATERIALS SCIENCE | 2015年 / 50卷 / 18期
关键词：
DRUG-RELEASE; EPIDEMIOLOGY; ANTICANCER;
D O I：
10.1007/s10853-015-9179-6
中图分类号：
T [工业技术];
学科分类号：
08 ;
摘要：
A series of dual-sensitive poly(2-hydroxyethyl acrylate/itaconic acid) (P(HEA/IA)) hydrogels were synthesized and evaluated as drug delivery systems for potential antiproliferative agents. Investigated hydrophobic compounds, Mn(II) and Zn(II) complexes with Oxaprozin, were efficiently loaded into the P(HEA/IA) hydrogels, which was confirmed by FTIR and UV-Vis spectroscopy. Swelling studies, conducted in the physiological pH range of 2.20-8.00 and in temperature range of 30-50 A degrees C, demonstrated that loaded transition metal complexes in P(HEA/IA) hydrogels did not annul pH and temperature sensitivity of the hydrogels. In vitro antiproliferative activity of Mn(II) and Zn(II) complexes with Oxaprozin against human cervical (HeLa) and melanoma cancer (Fem X) cell lines was tested. Results of in vitro release study investigated at different pH conditions confirmed P(HEA/IA) hydrogels as a highly effective pH-triggered drug delivery system for hydrophobic antiproliferative agents. These performances indicate that P(HEA/IA) hydrogels loaded with transition metal complexes can be further studied as a promising candidate for anticancer therapy, as well as for targeted treatment of intestine/colon cancers.
引用
收藏
页码：6208 / 6219
页数：12
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