Doxorubicin is a photocatalyst for the generation of H2O2

被引：5
作者：
Nawara, Krzysztof [1 ,2 ]
Krysinski, Pawel [2 ]
Blanchard, G. J. [1 ]
机构：
[1] Michigan State Univ, Dept Chem, E Lansing, MI 48824 USA
[2] Univ Warsaw, Dept Chem, PL-02093 Warsaw, Poland
来源：
RSC ADVANCES | 2012年 / 2卷 / 10期
基金：
美国国家科学基金会;
关键词：
HYDROGEN-PEROXIDE; HYDROXYL RADICALS; ANTHRACYCLINES; CARDIOTOXICITY; PHOTOREDUCTION; MITOCHONDRIA; DEGRADATION; ADRIAMYCIN; RESORUFIN;
D O I：
10.1039/c2ra20323e
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
We have investigated the photoreactivity of the chemotherapeutic agent doxorubicin. We demonstrate the ability of this compound to generate H2O2 catalytically as a result of auto-oxidation of its photoreduced form. H2O2 may accumulate in toxic levels in pharmaceutical preparations.
引用
收藏
页码：4059 / 4061
页数：3
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