Doxorubicin is a photocatalyst for the generation of H2O2

被引：5

作者：

Nawara, Krzysztof ^{[1
,2
]}

Krysinski, Pawel ^{[2
]}

Blanchard, G. J. ^{[1
]}

机构：

[1] Michigan State Univ, Dept Chem, E Lansing, MI 48824 USA

[2] Univ Warsaw, Dept Chem, PL-02093 Warsaw, Poland

来源：

RSC ADVANCES | 2012年 / 2卷 / 10期

基金：

美国国家科学基金会;

关键词：

HYDROGEN-PEROXIDE; HYDROXYL RADICALS; ANTHRACYCLINES; CARDIOTOXICITY; PHOTOREDUCTION; MITOCHONDRIA; DEGRADATION; ADRIAMYCIN; RESORUFIN;

D O I：

10.1039/c2ra20323e

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We have investigated the photoreactivity of the chemotherapeutic agent doxorubicin. We demonstrate the ability of this compound to generate H2O2 catalytically as a result of auto-oxidation of its photoreduced form. H2O2 may accumulate in toxic levels in pharmaceutical preparations.

引用

页码：4059 / 4061

页数：3

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