Regulation of Gene Expression by N6-methyladenosine in Cancer

被引：197
|
作者：
Liu, Jun [1 ,2 ,3 ]
Harada, Bryan T. [1 ,2 ,3 ]
He, Chuan [1 ,2 ,3 ,4 ]
机构：
[1] Univ Chicago, Dept Chem, 5735 S Ellis Ave, Chicago, IL 60637 USA
[2] Univ Chicago, Inst Biophys Dynam, Chicago, IL 60637 USA
[3] Howard Hughes Med Inst, Chicago, IL 60637 USA
[4] Univ Chicago, Dept Biochem & Mol Biol, 920 E 58Th St, Chicago, IL 60637 USA
来源：
TRENDS IN CELL BIOLOGY | 2019年 / 29卷 / 06期
基金：
美国国家卫生研究院;
关键词：
MESSENGER-RNA METHYLATION; METHYLTRANSFERASE METTL3 PROMOTES; SINGLE-NUCLEOTIDE-RESOLUTION; NUCLEAR-RNA; M(6)A METHYLTRANSFERASE; STEM; TRANSLATION; REVEALS; N6-METHYLADENOSINE; DIFFERENTIATION;
D O I：
10.1016/j.tcb.2019.02.008
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
As the most abundant mRNA modification in eukaryotic cells, N-6-methyladenosine (m(6)A) has recently emerged as an important regulator of gene expression. m(6)A modification can be deposited by m(6)A methyltransferases, removed by m(6)A demethylases, and recognized by different reader proteins. Numerous lines of evidence have shown that m(6)A methylation plays critical roles regulating gene expression in development and disease. In this review, we summarize the molecular and cellular function of m(6)A and highlight some key results which demonstrate the role of m(6)A in various cancers. Finally, we discuss future directions for research into m(6)A and its effects in cancer and the potential for targeting RNA modification in cancer treatment.
引用
收藏
页码：487 / 499
页数：13
相关论文
共 50 条
  • [1] Post-transcriptional regulation of antiviral gene expression by N6-methyladenosine
    McFadden, Michael J.
    McIntyre, Alexa B. R.
    Mourelatos, Haralambos
    Abell, Nathan S.
    Gokhale, Nandan S.
    Ipas, Helene
    Xhemalce, Blerta
    Mason, Christopher E.
    Horner, Stacy M.
    CELL REPORTS, 2021, 34 (09):
  • [2] RNA N6-methyladenosine methylation in post-transcriptional gene expression regulation
    Yue, Yanan
    Liu, Jianzhao
    He, Chuan
    GENES & DEVELOPMENT, 2015, 29 (13) : 1343 - 1355
  • [3] Regulation of Gene Expression Associated With the N6-Methyladenosine (m6A) Enzyme System and Its Significance in Cancer
    Tian, Shuoran
    Lai, Junzhong
    Yu, Tingting
    Li, Qiumei
    Chen, Qi
    FRONTIERS IN ONCOLOGY, 2021, 10
  • [4] The dynamic epitranscriptome: N6-methyladenosine and gene expression control
    Kate D. Meyer
    Samie R. Jaffrey
    Nature Reviews Molecular Cell Biology, 2014, 15 : 313 - 326
  • [5] The dynamic epitranscriptome: N6-methyladenosine and gene expression control
    Meyer, Kate D.
    Jaffrey, Samie R.
    NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2014, 15 (05) : 313 - 326
  • [6] N6-methyladenosine Steers RNA Metabolism and Regulation in Cancer
    Dong, Shenghua
    Wu, Yutong
    Liu, Yadi
    Weng, Hengyou
    Huang, Huilin
    CANCER COMMUNICATIONS, 2021, 41 (07) : 538 - 559
  • [7] N6-methyladenosine regulates PEDV replication and host gene expression
    Chen, Jianing
    Jin, Li
    Wang, Zemei
    Wang, Liyuan
    Chen, Qingbo
    Cui, Yaru
    Liu, Guangliang
    VIROLOGY, 2020, 548 : 59 - 72
  • [8] Regulation of N6-Methyladenosine in the Differentiation of Cancer Stem Cells and Their Fate
    Xu, Ya
    Liu, Jing
    Chen, Wen-Jia
    Ye, Qian-Qian
    Chen, Wen-Tian
    Li, Chun-Lan
    Wu, Hua-Tao
    FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 2020, 8
  • [9] Modulation of translation regulation by N6-methyladenosine in prostate cancer.
    Cotter, Kellie A.
    Meyer, Kate D.
    Benelli, Matteo
    Cohen, Sandra
    Jaffrey, Samie
    Demichelis, Francesca
    Rubin, Mark
    CANCER RESEARCH, 2018, 78 (16) : 47 - 47
  • [10] N6-methyladenosine enhances post-transcriptional gene regulation by microRNAs
    Kanoria, Shaveta
    Rennie, William A.
    Carmack, Charles Steven
    Lu, Jun
    Ding, Ye
    BIOINFORMATICS ADVANCES, 2022, 2 (01):
12345