The time is now: moving toward virus-specific T cells after allogeneic hematopoietic stem cell transplantation as the standard of care

被引：62

作者：

Saglio, Francesco ^{[1
]}

Hanley, Patrick J. ^{[2
,3
]}

Bollard, Catherine M. ^{[2
,3
]}

机构：

[1] Regina Margherita Childrens Hosp, Pediat Oncohematol Stem Cell Transplantat & Cell, Turin, Italy

[2] Childrens Natl Med Hlth Syst, Program Cell Enhancement & Technol Immunotherapy, Sheikh Zayed Inst Pediat Surg Innovat, Washington, DC USA

[3] Childrens Natl Med Hlth Syst, Ctr Canc & Immunol Res, Washington, DC USA

来源：

CYTOTHERAPY | 2014年 / 16卷 / 02期

关键词：

immunotherapy; stem cell transplantation; T cell; virus; EPSTEIN-BARR-VIRUS; ADOPTIVE TRANSFER; CORD BLOOD; LYMPHOPROLIFERATIVE DISEASE; ADENOVIRUS INFECTION; BONE-MARROW; CYTOMEGALOVIRUS DISEASE; PROPHYLACTIC INFUSION; PEDIATRIC RECIPIENTS; VIRAL-INFECTIONS;

D O I：

10.1016/j.jcyt.2013.11.010

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

Adoptive immunotherapy-in particular, T-cell therapy-has recently emerged as a useful strategy with the potential to overcome many of the limitations of antiviral drugs for the treatment of viral complications after hematopietic stem cell transplantation. In this review, we briefly summarize the current methods for virus-specific T-cell isolation or selection and we report results from clinical trials that have used these techniques, focusing specifically on the strategies aimed to broaden the application of this technology.

引用

页码：149 / 159

页数：11

共 63 条

[1] Successful treatment of EBV-associated posttransplantation lymphoma after cord blood transplantation using third-party EBV-specific cytotoxic T lymphocytes [J].

Barker, Juliet N. ;

Doubrovina, Ekaterina ;

Sauter, Craig ;

Jaroscak, Jennifer J. ;

Perales, Miguel A. ;

Doubrovin, Mikhail ;

Prockop, Susan E. ;

Koehne, Guenther ;

O'Reilly, Richard J. .

BLOOD, 2010, 116 (23) :5045-5049

[2] Donor-derived CMV-specific T cells reduce the requirement for CMV-directed pharmacotherapy after allogeneic stem cell transplantation [J].

Blyth, Emily ;

Clancy, Leighton ;

Simms, Renee ;

Ma, Chun K. K. ;

Burgess, Jane ;

Deo, Shivashni ;

Byth, Karen ;

Dubosq, Ming-Celine ;

Shaw, Peter J. ;

Micklethwaite, Kenneth P. ;

Gottlieb, David J. .

BLOOD, 2013, 121 (18) :3745-3758

[3] Late cytomegalovirus disease and mortality in recipients of allogeneic hematopoietic stem cell transplants: importance of viral load and T-cell immunity [J].

Boeckh, M ;

Leisenring, W ;

Riddell, SR ;

Bowden, RA ;

Huang, ML ;

Myerson, D ;

Stevens-Ayers, T ;

Flowers, MED ;

Cunningham, T ;

Corey, L .

BLOOD, 2003, 101 (02) :407-414

[4] Marked increased risk of Epstein-Barr virus-related complications with the addition of antithymocyte globulin to a nonmyeloablative conditioning prior to unrelated umbilical cord blood transplantation [J].

Brunstein, Claudio G. ;

Weisclorf, Daniel J. ;

DeFor, Todd ;

Barker, Juliet N. ;

Tolar, Jakub ;

van Burik, Jo-Anne H. ;

Wagner, John E. .

BLOOD, 2006, 108 (08) :2874-2880

[5] Adoptive transfer of cytomegalovirus-specific CTL to stem cell transplant patients after selection by HLA-peptide tetramers [J].

Cobbold, M ;

Khan, N ;

Pourgheysari, B ;

Tauro, S ;

McDonald, D ;

Osman, H ;

Assenmacher, M ;

Billingham, L ;

Steward, C ;

Crawley, C ;

Olavarria, E ;

Goldman, J ;

Chakraverty, R ;

Mahendra, P ;

Craddock, C ;

Moss, PAH .

JOURNAL OF EXPERIMENTAL MEDICINE, 2005, 202 (03) :379-386

[6] Preemptive therapy of EBV-related lymphoproliferative disease after pediatric haploidentical stem cell transplantation [J].

Comoli, P. ;

Basso, S. ;

Zecca, M. ;

Pagliara, D. ;

Baldanti, F. ;

Bernardo, M. E. ;

Barberi, W. ;

Moretta, A. ;

Labirio, M. ;

Paulli, M. ;

Furione, M. ;

Maccario, R. ;

Locatelli, F. .

AMERICAN JOURNAL OF TRANSPLANTATION, 2007, 7 (06) :1648-1655

[7] Adoptive immunotherapy with unselected or EBV-specific T cells for biopsy-proven EBV+ lymphomas after allogeneic hematopoietic cell transplantation [J].

Doubrovina, Ekaterina ;

Oflaz-Sozmen, Banu ;

Prockop, Susan E. ;

Kernan, Nancy A. ;

Abramson, Sara ;

Teruya-Feldstein, Julie ;

Hedvat, Cyrus ;

Chou, Joanne F. ;

Heller, Glenn ;

Barker, Juliet N. ;

Boulad, Farid ;

Castro-Malaspina, Hugo ;

George, Diane ;

Jakubowski, Ann ;

Koehne, Guenther ;

Papadopoulos, Esperanza B. ;

Scaradavou, Andromachi ;

Small, Trudy N. ;

Khalaf, Ramzi ;

Young, James W. ;

O'Reilly, Richard J. .

BLOOD, 2012, 119 (11) :2644-2656

[8] Infusion of cytomegalovirus (CMV)-specific T cells for the treatment of CMV infection not responding to antiviral chemotherapy [J].

Einsele, H ;

Roosnek, E ;

Rufer, N ;

Sinzger, C ;

Riegler, S ;

Löffler, J ;

Grigoleit, U ;

Moris, A ;

Rammensee, HG ;

Kanz, L ;

Kleihauer, A ;

Frank, F ;

Jahn, G ;

Hebart, H .

BLOOD, 2002, 99 (11) :3916-3922

[9] Safe adoptive transfer of virus-specific T-cell immunity for the treatment of systemic adenovirus infection after allogeneic stem cell transplantation [J].

Feuchtinger, T ;

Matthes-Martin, S ;

Richard, C ;

Lion, T ;

Fuhrer, M ;

Hamprecht, K ;

Handgretinger, R ;

Peters, C ;

Schuster, FR ;

Beck, R ;

Schumm, M ;

Lotfi, R ;

Jahn, G ;

Lang, P .

BRITISH JOURNAL OF HAEMATOLOGY, 2006, 134 (01) :64-76

[10] Isolation and expansion of human adenovirus-specific CD4+ and CD8+ T cells according to IFN-γ secretion for adjuvant immunotherapy [J].

Feuchtinger, T ;

Lang, P ;

Hamprecht, K ;

Schumm, M ;

Greil, J ;

Jahn, G ;

Niethammer, D ;

Einsele, H .

EXPERIMENTAL HEMATOLOGY, 2004, 32 (03) :282-289

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