The Advance of Gene Delivery Vectors

被引：1

作者：

Li Yan ^{[1
,2
]}

Yang Jun ^{[1
]}

Liu Gui-Ying ^{[3
]}

Zhang Xin ^{[1
]}

机构：

[1] Chinese Acad Sci, Inst Proc Engn, Natl Key Lab Biochem Engn, Beijing 100190, Peoples R China

[2] Univ Chinese Acad Sci, Beijing 100049, Peoples R China

[3] Capital Med Univ, Dept Pediat, Affiliated Beijing Anzhen Hosp, Beijing 100029, Peoples R China

来源：

PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS | 2013年 / 40卷 / 10期

基金：

中国国家自然科学基金;

关键词：

gene therapy; viral vectors; liposomes; polymers; dendrimers; POLY-L-LYSINE; SMALL INTERFERING RNA; MARROW STROMAL CELLS; SIRNA DELIVERY; IN-VIVO; NONVIRAL VECTORS; LIPID NANOPARTICLES; POLYETHYLENE-GLYCOL; CATIONIC LIPOSOMES; SYSTEMIC DELIVERY;

D O I：

10.3724/SP.J.1206.2013.00312

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Gene therapy has rapidly emerged as a promising method for the treatment of numerous diseases. However, the intrinsic deficiencies of gene-based drugs, such as enzymatic degradation in the body, poor membrane penetrability and lack of target ability, have limited the development of its therapeutic application. Herein, it is important for efficient gene therapy to develop efficient and safe gene vectors that can deliver the gene-based drugs to targeted cells. This paper reviews the current development in gene delivery vectors, especially summarizes the characteristic and development of viral vectors, non-viral vectors and nanoparticles with tracing ability.

引用

页码：998 / 1007

页数：10

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