Serum level of lipoprotein (a) is inversely associated with the development of coronary collateral circulation

被引:20
作者
Dursun, A
Geyik, B
Topaloglu, S
Ergun, K
Ayaz, S
Maden, O
Yildiz, A
Balci, M
Ozeke, O
Korkmaz, S
机构
[1] Turkiye Yuksek Ihtisas Hosp, Dept Cardiol, Ankara, Turkey
[2] Turkiye Yuksek Ihtisas Hosp, Dept Biochem, Ankara, Turkey
关键词
angiogenic growth factors; collateral circulation; lipoprotein (a);
D O I
10.1097/00019501-200603000-00010
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
This study sought to determine the relationship between serum lipoprotein (a) levels and angiographically visible coronary collateral circulation and to evaluate whether lipoprotein (a) exerts any effect on vascular endothelial cell growth factor. The study population included 60 patients (39 men, mean age 59 +/- 13 years) with angiographically documented total occlusion in one of the major coronary arteries. Development of collaterals was classified by Rentrop's method. Patients were defined as having poorly developed collaterals for grades 0 and 1 (group 1), or well-developed collaterals for grades 2 and 3 (group 2). Serum lipoprotein (a) and vascular endothelial cell growth factor levels were determined by enzyme-linked immunosorbent assay. In group 1, lipoprotein (a) levels were significantly higher and vascular endothelial cell growth factor levels were significantly lower than in group 2 (34 +/- 19 vs. 20 +/- 12 mg/dl, P < 0.001, and 25 +/- 0.7 vs. 3.4 +/- 0.8 mg/dl, P < 0.001, respectively). Poorly developed collaterals were significantly more frequent in patients with lipoprotein (a) levels >= 30 mg/dl than in patients with levels < 30 mg/dl (72 vs. 37%, P = 0.008). A strong negative correlation was observed between lipoprotein (a) and vascular endothelial cell growth, factor (r = -0.708, P < 0.0001). Multivariate analysis revealed that a high level of lipoprotein (a) negatively affected the development of collaterals, whereas the duration of angina had a positive effect. This study demonstrated for the first time that the high level of lipoprotein (a) negatively affects the formation of coronary collateral vessels in human beings. Reduced production or bioactivity of vascular endothelial cell growth factor caused by high levels of lipoprotein (a) may be the possible responsible mechanism of hyperlipoprotein (a)-related poor collateral formation.
引用
收藏
页码:159 / 163
页数:5
相关论文
共 27 条
[1]   VASCULAR ENDOTHELIAL GROWTH-FACTOR ACTS AS A SURVIVAL FACTOR FOR NEWLY FORMED RETINAL-VESSELS AND HAS IMPLICATIONS FOR RETINOPATHY OF PREMATURITY [J].
ALON, T ;
HEMO, I ;
ITIN, A ;
PEER, J ;
STONE, J ;
KESHET, E .
NATURE MEDICINE, 1995, 1 (10) :1024-1028
[2]   Hypertriglyceridemia and elevated lipoprotein(a) are risk factors for major coronary events in middle-aged men [J].
Assmann, G ;
Schulte, H ;
vonEckardstein, A .
AMERICAN JOURNAL OF CARDIOLOGY, 1996, 77 (14) :1179-1184
[3]   DETERMINANTS OF COLLATERAL FILLING OBSERVED DURING SUDDEN CONTROLLED CORONARY-ARTERY OCCLUSION IN HUMAN-SUBJECTS [J].
COHEN, M ;
SHERMAN, W ;
RENTROP, KP ;
GORLIN, R .
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 1989, 13 (02) :297-303
[4]   Molecular mechanisms of blood vessel growth [J].
Conway, EM ;
Collen, D ;
Carmeliet, P .
CARDIOVASCULAR RESEARCH, 2001, 49 (03) :507-521
[5]   ASSOCIATION OF LEVELS OF LIPOPROTEIN LP(A), PLASMA-LIPIDS, AND OTHER LIPOPROTEINS WITH CORONARY-ARTERY DISEASE DOCUMENTED BY ANGIOGRAPHY [J].
DAHLEN, GH ;
GUYTON, JR ;
ATTAR, M ;
FARMER, JA ;
KAUTZ, JA ;
GOTTO, AM .
CIRCULATION, 1986, 74 (04) :758-765
[6]  
Duan J, 2000, CIRCULATION, V102, P370
[7]   Use of vascular endothelial growth factor for therapeutic angiogenesis [J].
Engler, DA .
CIRCULATION, 1996, 94 (07) :1496-1498
[8]   ANGIOGENESIS IN CANCER, VASCULAR, RHEUMATOID AND OTHER DISEASE [J].
FOLKMAN, J .
NATURE MEDICINE, 1995, 1 (01) :27-31
[9]  
FUJITA M, 1991, CORONARY ARTERY DIS, V2, P815
[10]   PROLIFERATION OF HUMAN SMOOTH-MUSCLE CELLS PROMOTED BY LIPOPROTEIN(A) [J].
GRAINGER, DJ ;
KIRSCHENLOHR, HL ;
METCALFE, JC ;
WEISSBERG, PL ;
WADE, DP ;
LAWN, RM .
SCIENCE, 1993, 260 (5114) :1655-1658