HMG-CoA reductase is regulated by environmental salinity and its activity is essential for halotolerance in halophilic fungi

被引：12

作者：

Vaupotic, T. ^{[1
]}

Veranic, P. ^{[2
]}

Petrovic, U. ^{[3
]}

Gunde-Cimerman, N. ^{[4
]}

Plemenitas, A. ^{[1
]}

机构：

[1] Univ Ljubljana, Fac Med, Inst Biochem, Ljubljana 1000, Slovenia

[2] Univ Ljubljana, Fac Med, Inst Cell Biol, Ljubljana 1000, Slovenia

[3] Jozef Stefan Inst, Dept Biochem & Mol Biol, Ljubljana 1000, Slovenia

[4] Univ Ljubljana, Dept Biol, Biotech Fac, Ljubljana 1000, Slovenia

来源：

STUDIES IN MYCOLOGY | 2008年 / 61期

关键词：

Adaptation; extremophiles; isoprenylation; lovastatin; mevalonate regulation;

D O I：

10.3114/sim.2008.61.05

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The activity and level of HMG-CoA reductase (HMGR) were addressed in halophilic fungi isolated from solar saltpans. Representative fungi belonging to the orders Dothideales, Eurotiales and Wallemiales have a specific pattern of HMGR regulation, which differs from salt-sensitive and moderately salt-tolerant yeasts. In all of the halophilic fungi studied, HMGR amounts and activities were the lowest at optimal growth salinity and increased under hyposaline and hypersaline conditions. This profile paralleled isoprenylation of cellular proteins in H. wemeckii. Inhibition of HMGR in vivo by lovastatin impaired the halotolerant character. HMGR may thus serve as an important molecular marker of halotolerance.

引用

页码：61 / 66

页数：6

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