Modulation of multiple sclerosis by sunlight exposure: Role of cis-urocanic acid

被引：27

作者：

Correale, Jorge ^{[1
]}

Farez, Mauricio F. ^{[1
]}

机构：

[1] FLENI, Inst Neurol Res Dr Raul Carrea, Dept Neurol, RA-1428 Buenos Aires, DF, Argentina

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2013年 / 261卷 / 1-2期

关键词：

Multiple sclerosis; Urocanic acid; Environmental factors; Ultraviolet radiation; Cytokines; VITAMIN-D; ANTIGEN PRESENTATION; UV-RADIATION; RISK-FACTORS; SUPPRESSION; PREVALENCE; CELLS; SKIN;

D O I：

10.1016/j.jneuroim.2013.05.014

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The role of cis-urocanic acid (UCA) as a UV-mediated immunomodulator in MS patients was investigated. Plasma levels of cis-UCA were significantly lower in MS patients compared to controls. Stimulation of MBP- and MUG-specific T cells in the presence of cis-UCA, significantly increased IL-10, and inhibited IFN-gamma production. PBMCs cultured in the presence of cis-UCA increased CD4(+)CD25(+)FoxP3(+) regulatory T cell percentages. Dendritic cells cultured in the presence of cis-UCA significantly reduced Ag presentation capacity. Finally, cis-UCA activated the 5-HT2A receptor, inducing the increase in phosphorylated forms of ERK 1/2 and JNK2. Thus, in addition to vitamin D, cis-UCA also appears to be an additional UV-mediated immunomodulator. (C) 2013 Elsevier B.V. All rights reserved.

引用

页码：134 / 140

页数：7

共 28 条

[1] cis-Urocanic Acid Attenuates Acute Dextran Sodium Sulphate-Induced Intestinal Inflammation [J].

Albert, Eric ;

Walker, John ;

Thiesen, Aducio ;

Churchill, Thomas ;

Madsen, Karen .

PLOS ONE, 2010, 5 (10)

[2] MIGRATION AND RISK OF MULTIPLE-SCLEROSIS [J].

ALTER, M ;

KAHANA, E ;

LOEWENSON, R .

NEUROLOGY, 1978, 28 (11) :1089-1093

[3] Failed antigen presentation after UVB radiation correlates with modifications of Langerhans cell cytoskeleton [J].

Bacci, S ;

Nakamura, T ;

Streilein, JW .

JOURNAL OF INVESTIGATIVE DERMATOLOGY, 1996, 107 (06) :838-843

[4] UV radiation suppresses experimental autoimmune encephalomyelitis independent of vitamin D production [J].

Becklund, Bryan R. ;

Severson, Kyle S. ;

Vang, Souriya V. ;

DeLuca, Hector F. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2010, 107 (14) :6418-6423

[5] IL-12 prevents the inhibitory effects of cis-urocanic acid on tumor antigen presentation by Langerhans cells:: Implications for photocarcinogenesis [J].

Beissert, S ;

Rühlemann, D ;

Mohammad, T ;

Grabbe, S ;

El-Ghorr, A ;

Norval, M ;

Morrison, H ;

Granstein, RD ;

Schwarz, T .

JOURNAL OF IMMUNOLOGY, 2001, 167 (11) :6232-6238

[6] ISOLATION AND CHARACTERIZATION OF AUTOREACTIVE PROTEOLIPID PROTEIN-PEPTIDE SPECIFIC T-CELL CLONES FROM MULTIPLE-SCLEROSIS PATIENTS [J].

CORREALE, J ;

MCMILLAN, M ;

MCCARTHY, K ;

LE, T ;

WEINER, LP .

NEUROLOGY, 1995, 45 (07) :1370-1378

[7] Monocyte-derived dendritic cells in multiple sclerosis: The effect of bacterial infection [J].

Correale, Jorge ;

Farez, Mauricio .

JOURNAL OF NEUROIMMUNOLOGY, 2007, 190 (1-2) :177-189

[8] Immunomodulatory effects of Vitamin D in multiple sclerosis [J].

Correale, Jorge ;

Celica Ysrraelit, Mara ;

Ines Gaitan, Maria .

BRAIN, 2009, 132 :1146-1160

[9] Recent advances in urocanic acid photochemistry, photobiology and photoimmunology [J].

Gibbs, Neil K. ;

Tye, Joanne ;

Norval, Mary .

PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES, 2008, 7 (06) :655-667

[10] INHIBITION OF SKIN ALLOGRAFT-REJECTION AND ACUTE GRAFT-VERSUS-HOST DISEASE BY CIS-UROCANIC ACID [J].

GRUNER, S ;

DIEZEL, W ;

STOPPE, H ;

OESTERWITZ, H ;

HENKE, W .

JOURNAL OF INVESTIGATIVE DERMATOLOGY, 1992, 98 (04) :459-462

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