Genome-wide association study of co-occurring anxiety in major depression

被引：14

作者：

Schosser, Alexandra ^{[1
,17
]}

Butler, Amy W. ^{[1
]}

Uher, Rudolf ^{[1
]}

Ng, Mandy Y. ^{[1
]}

Cohen-Woods, Sarah ^{[1
]}

Craddock, Nick ^{[2
]}

Owen, Mike J. ^{[2
]}

Korszun, Ania ^{[3
]}

Gill, Michael ^{[4
]}

Rice, John ^{[5
]}

Hauser, Joanna ^{[6
]}

Henigsberg, Neven ^{[7
]}

Maier, Wolfgang ^{[8
]}

Mors, Ole ^{[9
]}

Placentino, Anna ^{[10
,11
]}

Rietschel, Marcella ^{[12
]}

Souery, Daniel ^{[13
,14
]}

Preisig, Martin ^{[15
,16
]}

Craig, Ian W. ^{[1
]}

Farmer, Anne E. ^{[1
]}

Lewis, Cathryn M. ^{[1
]}

McGuffin, Peter ^{[1
]}

机构：

[1] Kings Coll London, MRC, SGDP Ctr, Inst Psychiat, London, England

[2] Cardiff Univ, Dept Psychol Med & Neurol, Ctr Neuropsychiat Genet & Gen, MRC, Cardiff CF10 3AX, S Glam, Wales

[3] Queen Mary Univ London, Barts & London Med Sch, London, England

[4] Trinity Ctr Hlth Sci, Dept Psychiat, Dublin, Ireland

[5] Washington Univ, Dept Psychiat, St Louis, MO USA

[6] Poznan Univ Med Sci, Dept Psychiat, Lab Psychiat Genet, Poznan, Poland

[7] Univ Zagreb, Sch Med, Croatian Inst Brain Res, Zagreb 41001, Croatia

[8] Univ Bonn, Dept Psychiat, Bonn, Germany

[9] Aarhus Univ Hosp, Ctr Psychiat Res, Risskov, Denmark

[10] FBF, Ctr San Giovanni di Dio, Biol Psychiat Unit, Brescia, Italy

[11] FBF, Ctr San Giovanni di Dio, Dual Diag Ward IRCCS, Brescia, Italy

[12] Cent Inst Mental Hlth, Div Genet Epidemiol Psychiat, Mannheim, Germany

[13] Univ Libre Bruxelles, Lab Psychol Med, Brussels, Belgium

[14] Psy Pluriel Ctr Europeen Psychol Med, Liege, Belgium

[15] Univ Hosp Ctr, Lausanne, Switzerland

[16] Univ Lausanne, Lausanne, Switzerland

[17] Med Univ Vienna, Dept Psychiat & Psychotherapy, A-1090 Vienna, Austria

来源：

WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY | 2013年 / 14卷 / 08期

基金：

奥地利科学基金会; 英国医学研究理事会;

关键词：

GWAS; anxiety; MDD; association; depression; ELEMENT-BINDING PROTEIN; DSM-IV DISORDERS; CAMP RESPONSE; ANXIOUS DEPRESSION; GABA(A) RECEPTORS; PREDICT RESPONSE; PANIC DISORDER; LOW-RISK; DYSTROPHIN; LINKAGE;

D O I：

10.3109/15622975.2013.782107

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Objectives. Co-morbidity between depression and anxiety disorders is common. In this study we define a quantitative measure of anxiety by summating four anxiety items from the SCAN interview in a large collection of major depression (MDD) cases to identify genes contributing to this complex phenotype. Methods. A total of 1522 MDD cases dichotomised according to those with at least one anxiety item scored (n = 1080) and those without anxiety (n = 442) were analysed, and also compared to 1588 healthy controls at a genome-wide level, to identify genes that may contribute to anxiety in MDD. Results. For the quantitative trait, suggestive evidence of association was detected for two SNPs, and for the dichotomous anxiety present/absent ratings for three SNPs at genome-wide level. In the genome-wide analysis of MDD cases with co-morbid anxiety and healthy controls, two SNPs attained P values of < 5 X 10(-6). Analysing candidate genes, P values <= 0.0005 were found with three SNPs for the quantitative trait and three SNPs for the dichotomous trait. Conclusions. This study provides an initial genome-wide assessment of possible genetic contribution to anxiety in MDD. Although suggestive evidence of association was found for several SNPs, our findings suggest that there are no common variants strongly associated with anxious depression.

引用

页码：611 / 621

页数：11