Expression of lymphocyte-derived growth hormone (GH) and GH-releasing hormone receptors in aging rats

被引：12
|
作者：
Weigent, Douglas A. [1 ]
机构：
[1] Univ Alabama Birmingham, Dept Cell Dev & Integrat Biol, Birmingham, AL 35294 USA
来源：
CELLULAR IMMUNOLOGY | 2013年 / 282卷 / 02期
关键词：
Growth hormone; GHRH receptors; Lymphocytes; Aging; FACTOR-I; MONONUCLEAR LEUKOCYTES; MESSENGER-RNA; IMMUNE-SYSTEM; INTERFERON-GAMMA; BINDING-SITES; T-LYMPHOCYTE; CELLS; INSULIN; PITUITARY;
D O I：
10.1016/j.cellimm.2013.04.009
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
In the present study, we show that higher levels of lymphocyte GH are expressed in spleen cells from aging animals compared to young animals. Further, leukocytes from primary and secondary immune tissues and splenic T and B cells from aging rats all express higher levels of GHRH receptors compared to younger animals. Bone marrow and splenic T cells express the highest levels of GHRH receptor in aging animals. Spleen cells from aging animals showed no significant change in proliferation or GH induction after treatment with GHRH. Taken together, the data for the first time show alterations in GH synthesis and expression of the GHRH receptor on cells of the immune system that may play a role in the immune response in aging. (C) 2013 Elsevier Inc. All rights reserved.
引用
收藏
页码：71 / 78
页数：8
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