Cellulase for commodity products from cellulosic biomass

被引:203
作者
Himmel, ME
Ruth, MF
Wyman, CE
机构
[1] Natl Renewable Energy Lab, Golden, CO 80401 USA
[2] Dartmouth Coll, Thayer Sch Engn, Hanover, NH 03755 USA
关键词
D O I
10.1016/S0958-1669(99)80065-2
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
A vital objective for second millennium biotechnology will be the enzymatic conversion of renewable cellulosic biomass to inexpensive fermentable sugars; new and more efficient fermentation processes will convert this biological 'currency' to a variety of commodity products. Although early strides will be made using process development and engineering disciplines, mid-term and longer advances must rely heavily on insight gained through protein and metabolic engineering technologies. These challenging goats can be met most effectively by the full integration of academic, federal, and industrial efforts in teams that develop and apply new fundamental knowledge to key cost drivers.
引用
收藏
页码:358 / 364
页数:7
相关论文
共 45 条
  • [1] When blind is better: Protein design by evolution
    Arnold, FH
    [J]. NATURE BIOTECHNOLOGY, 1998, 16 (07) : 617 - 618
  • [2] BOISSET C, 1998, CARBOHYDRASES TRICHO, P124
  • [3] CHANG V, 1999, P 21 S BIOT FUELD CH, P1
  • [4] A MODEL OF ENZYME ADSORPTION AND HYDROLYSIS OF MICROCRYSTALLINE CELLULOSE WITH SLOW DEACTIVATION OF THE ADSORBED ENZYME
    CONVERSE, AO
    MATSUNO, R
    TANAKA, M
    TANIGUCHI, M
    [J]. BIOTECHNOLOGY AND BIOENGINEERING, 1988, 32 (01) : 38 - 45
  • [5] DNA shuffling of a family of genes from diverse species accelerates directed evolution
    Crameri, A
    Raillard, SA
    Bermudez, E
    Stemmer, WPC
    [J]. NATURE, 1998, 391 (6664) : 288 - 291
  • [6] DEBARY, 1886, BOT Z, V44, P377
  • [7] CELLULASE - A PERSPECTIVE
    EVELEIGH, DE
    [J]. PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES, 1987, 321 (1561): : 435 - +
  • [8] FRY SC, 1989, ACS SYM SER, V399, P33
  • [9] Grohmann K., 1986, BIOTECHNOL BIOENG S, V15, P59, DOI DOI 10.1016/J.BIORTECH.2011.02.045
  • [10] HAYWARD TK, 1999, P 21 S BIOT FUELS CH