A cleavage-site-directed inhibitor of interleukin 1 beta-converting enzyme-like proteases inhibits apoptosis in primary cultures of rat hepatocytes

被引：73

作者：

Cain, K

InayatHussain, SH

Couet, C

Cohen, GM

机构：

[1] MRC Toxicology Unit, Hodgkin Building, Leicester LE1 9HN, Lancaster Rd.

来源：

BIOCHEMICAL JOURNAL | 1996年 / 314卷

关键词：

D O I：

10.1042/bj3140027

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Apoptosis induced in primary hepatocytes by transforming growth factor beta(1) and staurosporine produces chromatin condensation, DNA cleavage as detected by in situ end-labelling, field inversion and conventional gel electrophoresis, and cell detachment. These effects were abolished by benzyloxycarbonyl-valinylalanylaspartylfluoromethyl ketone, a cleavage-site-directed inhibitor of interleukin-1 beta-converting enzyme-like proteases, and this finding suggests that these enzymes are involved in liver apoptosis.

引用

页码：27 / 32

页数：6

共 38 条

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