A cleavage-site-directed inhibitor of interleukin 1 beta-converting enzyme-like proteases inhibits apoptosis in primary cultures of rat hepatocytes

被引：73
|
作者：
Cain, K
InayatHussain, SH
Couet, C
Cohen, GM
机构：
[1] MRC Toxicology Unit, Hodgkin Building, Leicester LE1 9HN, Lancaster Rd.
来源：
BIOCHEMICAL JOURNAL | 1996年 / 314卷
关键词：
D O I：
10.1042/bj3140027
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Apoptosis induced in primary hepatocytes by transforming growth factor beta(1) and staurosporine produces chromatin condensation, DNA cleavage as detected by in situ end-labelling, field inversion and conventional gel electrophoresis, and cell detachment. These effects were abolished by benzyloxycarbonyl-valinylalanylaspartylfluoromethyl ketone, a cleavage-site-directed inhibitor of interleukin-1 beta-converting enzyme-like proteases, and this finding suggests that these enzymes are involved in liver apoptosis.
引用
收藏
页码：27 / 32
页数：6
相关论文
共 33 条
  • [1] Cleavage of retinoblastoma protein during apoptosis: An interleukin 1 beta-converting enzyme-like protease as candidate
    An, B
    Dou, QP
    CANCER RESEARCH, 1996, 56 (03) : 438 - 442
  • [2] Interleukin-1 beta-converting enzyme-like apoptosis protease 3 and 4
    不详
    EXPERT OPINION ON THERAPEUTIC PATENTS, 1996, 6 (10) : 1093 - 1096
  • [3] BAX-induced cell death may not require interleukin 1 beta-converting enzyme-like proteases
    Xiang, JL
    Chao, DT
    Korsmeyer, SJ
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (25) : 14559 - 14563
  • [4] Apoptosis in cerebellar granule neurones: Involvement of interleukin-1 beta converting enzyme-like proteases
    Taylor, J
    Gatchalian, CL
    Keen, G
    Rubin, LL
    JOURNAL OF NEUROCHEMISTRY, 1997, 68 (04) : 1598 - 1605
  • [5] Failure to activate interleukin 1 beta-converting enzyme-like proteases and to cleave retinoblastoma protein in drug-resistant cells
    An, B
    Jin, JR
    Lin, P
    Dou, QP
    FEBS LETTERS, 1996, 399 (1-2) : 158 - 162
  • [6] Heteronuclear ribonucleoproteins C1 and C2, components of the spliceosome, are specific targets of interleukin 1 beta-converting enzyme-like proteases in apoptosis
    Waterhouse, N
    Kumar, S
    Song, QH
    Strike, P
    Sparrow, L
    Dreyfuss, G
    Alnemri, ES
    Litwack, G
    Lavin, M
    Watters, D
    JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (46) : 29335 - 29341
  • [7] Interleukin 1 beta converting enzyme-like proteases are essential for p53-mediated transcriptionally dependent apoptosis
    Sabbatini, P
    Han, J
    Chiou, SK
    Nicholson, DW
    White, E
    CELL GROWTH & DIFFERENTIATION, 1997, 8 (06): : 643 - 653
  • [8] AN INTERLEUKIN-1-BETA-CONVERTING ENZYME-LIKE PROTEASE IS A COMMON MEDIATOR OF APOPTOSIS IN THYMOCYTES
    FEARNHEAD, HO
    DINSDALE, D
    COHEN, GM
    FEBS LETTERS, 1995, 375 (03): : 283 - 288
  • [9] Inhibitors of interleukin-1 beta-converting enzyme and other proteases attenuate apoptosis in cultured porcine granulosa cells.
    Guthrie, HD
    Garrett, WM
    Cooper, BS
    BIOLOGY OF REPRODUCTION, 1997, 56 : 569 - 569
  • [10] Interleukin 1 beta-converting enzyme related proteases/caspases are involved in TRAIL-induced apoptosis of myeloma and leukemia cells
    Mariani, SM
    Matiba, B
    Armandola, EA
    Krammer, PH
    JOURNAL OF CELL BIOLOGY, 1997, 137 (01): : 221 - 229
1234