Synthesis of Stable Acyclic Aminals Derived from L-(+)-Aspartic Acid and Their Application in Asymmetric Henry Reactions

被引：1

作者：

Koz, Gamze ^{[1
]}

Astley, Demet ^{[1
]}

Astley, Stephen T. ^{[1
]}

机构：

[1] Ege Univ, Dept Chem, Fac Sci, TR-35100 Izmir, Turkey

来源：

ZEITSCHRIFT FUR NATURFORSCHUNG SECTION B-A JOURNAL OF CHEMICAL SCIENCES | 2013年 / 68卷 / 01期

关键词：

Acyclic Aminals; L-(+)-Aspartic Acid; Enantioselective Henry Reaction; NITROALDOL REACTIONS; COMPLEXES; ORGANOCATALYSIS; ALDEHYDES; KETONES;

D O I：

10.5560/ZNB.2013-2228

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

A series of stable acyclic aminals derived from L-(+)-aspartic acid were synthesized in excellent yields (up to 96%) and characterized by spectroscopic methods. They were applied as enantioselective catalysts in Henry reactions of nitromethane with various aldehydes in the presence of Cu(II) ions, affording the corresponding adducts in high yields (up to 90%) and enantioselectivities (up to 92% ee).

引用

页码：57 / 63

页数：7

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