Can the gut be the missing piece in uncovering PD pathogenesis?

被引：47

作者：

Chapelet, Guillaume ^{[1
,2
,3
]}

Leclair-Visonneau, Laurene ^{[1
,2
,3
,4
]}

Clairembault, Thomas ^{[1
,2
]}

Neunlist, Michel ^{[1
,2
]}

Derkinderen, Pascal ^{[1
,2
,3
,5
]}

机构：

[1] INSERM, Fac Med, U1235, 1 Rue Gaston Veil, F-44035 Nantes, France

[2] Univ Nantes, Fac Med, 1 Rue Gaston Veil, F-44035 Nantes, France

[3] CHU Nantes, Clin Gerontol Dept, Bd Jacques Monod, F-44093 Nantes, France

[4] CHU Nantes, Dept Clin Neurophysiol, Bd Jacques Monod, F-44093 Nantes, France

[5] CHU Nantes, Dept Neurol, Bd Jacques Monod, F-44093 Nantes, France

来源：

PARKINSONISM & RELATED DISORDERS | 2019年 / 59卷

关键词：

Parkinson's disease; Gut-brain axis; Enteric nervous system; Gut microbiota; Inflammation; Intestinal epithelial barrier; PARKINSONS-DISEASE; INTESTINAL PERMEABILITY; MICROBIOTA; INFLAMMATION; INVOLVEMENT; PATHOLOGY; SYSTEM;

D O I：

10.1016/j.parkreldis.2018.11.014

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

It is now well established that Parkinson's disease (PD) is not only a movement disorder of the CNS but also a gastrointestinal disorder affecting the enteric nervous system (ENS). The gut-brain axis is a bidirectional communication between the brain and the gastrointestinal tract, which comprises besides the CNS and the ENS, the intestinal epithelial barrier, the intestinal microbiota and the enteroendocrine systems. In this review, we present the clinical and pathological evidence suggesting that the gut-brain axis is dysfunctional in PD by discussing the possible role of gut microbiota, inflammation and permeability in the development of the disease.

引用

页码：26 / 31

页数：6