Can the gut be the missing piece in uncovering PD pathogenesis?

被引：47
作者：
Chapelet, Guillaume [1 ,2 ,3 ]
Leclair-Visonneau, Laurene [1 ,2 ,3 ,4 ]
Clairembault, Thomas [1 ,2 ]
Neunlist, Michel [1 ,2 ]
Derkinderen, Pascal [1 ,2 ,3 ,5 ]
机构：
[1] INSERM, Fac Med, U1235, 1 Rue Gaston Veil, F-44035 Nantes, France
[2] Univ Nantes, Fac Med, 1 Rue Gaston Veil, F-44035 Nantes, France
[3] CHU Nantes, Clin Gerontol Dept, Bd Jacques Monod, F-44093 Nantes, France
[4] CHU Nantes, Dept Clin Neurophysiol, Bd Jacques Monod, F-44093 Nantes, France
[5] CHU Nantes, Dept Neurol, Bd Jacques Monod, F-44093 Nantes, France
来源：
PARKINSONISM & RELATED DISORDERS | 2019年 / 59卷
关键词：
Parkinson's disease; Gut-brain axis; Enteric nervous system; Gut microbiota; Inflammation; Intestinal epithelial barrier; PARKINSONS-DISEASE; INTESTINAL PERMEABILITY; MICROBIOTA; INFLAMMATION; INVOLVEMENT; PATHOLOGY; SYSTEM;
D O I：
10.1016/j.parkreldis.2018.11.014
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
It is now well established that Parkinson's disease (PD) is not only a movement disorder of the CNS but also a gastrointestinal disorder affecting the enteric nervous system (ENS). The gut-brain axis is a bidirectional communication between the brain and the gastrointestinal tract, which comprises besides the CNS and the ENS, the intestinal epithelial barrier, the intestinal microbiota and the enteroendocrine systems. In this review, we present the clinical and pathological evidence suggesting that the gut-brain axis is dysfunctional in PD by discussing the possible role of gut microbiota, inflammation and permeability in the development of the disease.
引用
收藏
页码：26 / 31
页数：6
相关论文
共 61 条
[51]   The human enteric nervous system [J].
Schemann, M ;
Neunlist, M .
NEUROGASTROENTEROLOGY AND MOTILITY, 2004, 16 :55-59
[52]   Gut Microbiota Are Related to Parkinson's Disease and Clinical Phenotype [J].
Scheperjans, Filip ;
Aho, Velma ;
Pereira, Pedro A. B. ;
Koskinen, Kaisa ;
Paulin, Lars ;
Pekkonen, Eero ;
Haapaniemi, Elena ;
Kaakkola, Seppo ;
Eerola-Rautio, Johanna ;
Pohja, Marjatta ;
Kinnunen, Esko ;
Murros, Kari ;
Auvinen, Petri .
MOVEMENT DISORDERS, 2015, 30 (03) :350-358
[53]   Fecal markers of intestinal inflammation and intestinal permeability are elevated in Parkinson's disease [J].
Schwiertz, Andreas ;
Spiegel, Joerg ;
Dillmann, Ulrich ;
Grundmann, David ;
Buermann, Jan ;
Fassbender, Klaus ;
Schaefer, Karl-Herbert ;
Unger, Marcus M. .
PARKINSONISM & RELATED DISORDERS, 2018, 50 :104-107
[54]   Assessment of neuroinflammation in patients with idiopathic rapid-eye-movement sleep behaviour disorder: a case-control study [J].
Stokholm, Morten Gersel ;
Iranzo, Alex ;
Ostergaard, Karen ;
Serradell, Monica ;
Otto, Marit ;
Svendsen, Kristina Bacher ;
Garrido, Alicia ;
Vilas, Dolores ;
Borghammer, Per ;
Santamaria, Joan ;
Moller, Arne ;
Gaig, Carles ;
Brooks, David J. ;
Tolosa, Eduardo ;
Pavese, Nicola .
LANCET NEUROLOGY, 2017, 16 (10) :789-796
[55]   Postnatal microbial colonization programs the hypothalamic-pituitary-adrenal system for stress response in mice [J].
Sudo, N ;
Chida, Y ;
Aiba, Y ;
Sonoda, J ;
Oyama, N ;
Yu, XN ;
Kubo, C ;
Koga, Y .
JOURNAL OF PHYSIOLOGY-LONDON, 2004, 558 (01) :263-275
[56]   Regulation of intestinal epithelial permeability by tight junctions [J].
Suzuki, Takuya .
CELLULAR AND MOLECULAR LIFE SCIENCES, 2013, 70 (04) :631-659
[57]   Cyclooxygenase-2 is instrumental in Parkinson's disease neurodegeneration [J].
Teismann, P ;
Tieu, K ;
Choi, DK ;
Wu, DC ;
Naini, A ;
Hunot, S ;
Vila, M ;
Jackson-Lewis, V ;
Przedborski, S .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (09) :5473-5478
[58]   Parkinson's disease and bacteriophages as its overlooked contributors [J].
Tetz, George ;
Brown, Stuart M. ;
Hao, Yuhan ;
Tetz, Victor .
SCIENTIFIC REPORTS, 2018, 8
[59]   Short chain fatty acids and gut microbiota differ between patients with Parkinson's disease and age-matched controls [J].
Unger, Marcus M. ;
Spiegel, Joerg ;
Dillmann, Klaus-Ulrich ;
Grundmann, David ;
Philippeit, Hannah ;
Buermann, Jan ;
Fassbender, Klaus ;
Schwiertz, Andreas ;
Schaefer, Karl-Herbert .
PARKINSONISM & RELATED DISORDERS, 2016, 32 :66-72
[60]   Inflammatory bowel disease increases the risk of Parkinson's disease: a Danish nationwide cohort study 1977-2014 [J].
Villumsen, Marie ;
Aznar, Susana ;
Pakkenberg, Bente ;
Jess, Tine ;
Brudek, Tomasz .
GUT, 2019, 68 (01) :18-24
1234567