Role of complexes formation between drugs and penetration enhancers in transdermal delivery

被引：28

作者：

Drakulic, Branko J. ^{[2
]}

Juranic, Ivan O. ^{[3
]}

Eric, Slavica ^{[4
]}

Zloh, Mire ^{[1
]}

机构：

[1] Univ London, Sch Pharm, Dept Pharmaceut & Biol Chem, London WC1N 1AX, England

[2] Univ Belgrade, Dept Chem, Inst Chem Technol & Met, Belgrade 11000, Serbia

[3] Univ Belgrade, Fac Chem, Belgrade 11000, Serbia

[4] Fac Pharm, Belgrade 11000, Serbia

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 2008年 / 363卷 / 1-2期

关键词：

Conformational search; Small molecule-small molecule; interactions; Transdermal delivery; Penetration enhancers;

D O I：

10.1016/j.ijpharm.2008.06.032

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The use of chemical penetration enhancers (CPE) is growing due to their ability to improve drug delivery through the skin. A possible mechanism of penetration enhancement could involve the complex formation between drug and components in the pharmaceutical formulation, thus altering the physicochemical properties of the active substance. Here, modelling studies indicate that hydrocarbon and oxygen-containing terpenes (penetration enhancers) could form complexes with drugs. Satisfactory correlations have been obtained between the predicted molecular properties of enhancers and their enhancement effects. Crown Copyright (c) 2008 Published by Elsevier B.V. All rights reserved.

引用

页码：40 / 49

页数：10

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