Clinicopathological and immunohistochemical analysis of malignant features in mucinous cystic tumors of the pancreas

被引：0

作者：

Sawai, H ^{[1
]}

Okada, Y ^{[1
]}

Funahashi, H ^{[1
]}

Matsuo, Y ^{[1
]}

Hayakawa, T ^{[1
]}

Tanaka, M ^{[1
]}

Takeyama, H ^{[1
]}

Manabe, T ^{[1
]}

机构：

[1] Nagoya City Univ, Grad Sch Med Sci, Dept Surg Gastroenterol, Mizuho Ku, Nagoya, Aichi 4678601, Japan

来源：

HEPATO-GASTROENTEROLOGY | 2006年 / 53卷 / 68期

关键词：

immuno-histochemistry; integrins; intedeukin-1receptor type I; mucinous cystic tumors; p53; protein; pancreatic neoplasm;

D O I：

暂无

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Background/Aims: To investigate the malignancy of mucinous cystic tumors (MCTs) of the pancreas, we examined cliniccipathological features and immunohistochemical findings of MCT. Methodology: We analyzed the expression of p53 protein, proliferating cell nuclear antigen, alpha 6-integrin subunit, a(5)beta(1)-integrin, and interleukin-1 receptor type I in tumor specimens from eight patients with MCT. Results: The tumors were classified as mucinous cyst adenoma. (n=6) or mucinous cyst adenocarcino-ma (n=2). The actuarial five-year survival rate was 83.3%. All in eight MCTs had 'ovarian-type' stroma in the cyst wall. The alpha(6)-integrin subunit and p53 protein were expressed in adenocarcinoma tissues of MCTs, and in two adenomas the alpha(6)-integrin subunit and p53,protein were also co-expressed. Conclusions: Our present results indicate that co-expression of the alpha(6)-integrin subunit and p53 protein should be appreciated as an indicator of malignancy in MCTs.

引用

页码：286 / 290

页数：5

共 25 条

[11]

Kawahira H, 2000, HEPATO-GASTROENTEROL, V47, P973

[12]

Lan HA, 1996, ANTICANCER RES, V16, P3059

[13] Intraductal papillary-mucinous tumors of the pancreas: Clinicopathologic features, outcome, and nomenclature [J].