An efficient synthesis of 6-benzyl-2-arylthieno[2,3-d]pyrimidin-4(3H)-ones catalyzed byHClinvolving aFriedel-Craftsalkylation reaction

被引：0
|
作者：
Pan, Wan-Chen [1 ]
Wang, Yi-Chun [1 ]
Li, Tuan-Jie [1 ]
Liu, Jian-Quan [1 ]
Wang, Xiang-Shan [1 ]
机构：
[1] Jiangsu Normal Univ, Jiangsu Key Lab Green Synth Funct Mat, Sch Chem & Mat Sci, Xuzhou 221116, Jiangsu, Peoples R China
来源：
JOURNAL OF HETEROCYCLIC CHEMISTRY | 2020年 / 57卷 / 11期
关键词：
AQUEOUS-MEDIA; DERIVATIVES; ANTICANCER; APOPTOSIS; IODINE; HETEROCYCLES; ALKYLATION; COMPONENTS; INHIBITORS; DISCOVERY;
D O I：
10.1002/jhet.4107
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Aldehyde could undergo not only the subsequent condensation and cyclization with 2-aminothiophene-3-carboxamide to build a pyrimidine ring, but also a Friedel-Crafts alkylation reaction with thiophene moiety to give unexpected 6-benzyl-2-arylthieno[2,3-d]pyrimidin-4(3H)- ones in good yields catalyzed by concentrated HCl.
引用
收藏
页码：3970 / 3979
页数：10
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