Iridium-Catalyzed Asymmetric Hydrogenation of α-Alkylidene Succinimides

被引：103
作者：
Liu, Yuanyuan [1 ]
Zhang, Wanbin [1 ]
机构：
[1] Shanghai Jiao Tong Univ, Sch Chem & Chem Engn, Shanghai 200240, Peoples R China
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2013年 / 52卷 / 08期
基金：
中国国家自然科学基金;
关键词：
asymmetric catalysis; hydrogenation; iridium; ligand effects; synthetic methods; HIGHLY ENANTIOSELECTIVE HYDROGENATION; SPIRO AMINOPHOSPHINE LIGANDS; DIELS-ALDER REACTIONS; OXAZOLINE LIGANDS; 1,3-DIPOLAR CYCLOADDITIONS; ALLYLIC ALKYLATION; CARBONYL-COMPOUNDS; C(SP(3))-H BONDS; CHIRAL SWITCH; COMPLEXES;
D O I：
10.1002/anie.201209126
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Not to be out PhOXed! The title reaction provides a new approach to chiral succinimide derivatives with excellent yields and ee values by using a low catalyst loading (0.05 mol %) and mild reaction conditions. Chiral 3-benzyl pyrrolidines and 1-hydroxypyrrolidine-2,5-diones, important structural motifs in natural products and pharmaceuticals, could be readily prepared. BARF -=tetrakis[3,5-bis(trifluoromethyl)phenyl]borate. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
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页码：2203 / 2206
页数：4
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