Role of the CD200-CD200R Axis During Homeostasis and Neuroinflammation

被引：81

作者：

Manich, Gemma ^{[1
]}

Recasens, Mireia ^{[1
]}

Valente, Tony ^{[1
]}

Almolda, Beatriz ^{[1
]}

Gonzalez, Berta ^{[1
]}

Castellano, Bernardo ^{[1
]}

机构：

[1] Univ Autonoma Barcelona, Inst Neurosci, Dept Cell Biol Physiol & Immunol, E-08193 Barcelona, Spain

来源：

NEUROSCIENCE | 2019年 / 405卷

关键词：

off-receptor; immunoregulation; EAE; microglia-neuron communication; neurodegeneration; microglial priming; CENTRAL-NERVOUS-SYSTEM; SERUM-SOLUBLE CD200; MOUSE MODELS; MICROGLIAL ACTIVATION; INHIBITORY MOLECULES; CD200-DEFICIENT MICE; NEURONAL EXPRESSION; RESIDENT MICROGLIA; OX2; GLYCOPROTEIN; DOWN-REGULATION;

D O I：

10.1016/j.neuroscience.2018.10.030

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Microglia are considered to be the resident macrophages of the CNS and main effector of immune brain function. Due to their essential role in the regulation of neuroinflammatory response, microglia constitute an important target for neurological diseases, such as multiple sclerosis, Alzheimer's or Parkinson's disease. The communication between neurons and microglia contributes to a proper maintenance of homeostasis in the CNS. Research developed in the last decade has demonstrated that this interaction is mediated by "Off-signals" - molecules exerting immune inhibition - and "On signals" - molecules triggering immune activation. Among "Off signals", molecular pair CD200 and its CD200R receptor, expressed mainly in the membrane of neurons and microglia, respectively, have centered our attention due to its unexplored and powerful immunoregulatory functions. In this review, we will offer an updated global view of the CD200-CD200R role in the microglia-neuron crosstalk during homeostasis and neuroinflammation. Specifically, the effects of CD200-CD200R in the inhibition of pro-inflammatory microglial activation will be explained, and their involvement in other functions such as homeostasis preservation, tissue repair, and brain aging, among others, will be pointed out. In addition, we will depict the effects of CD200-CD200R uncoupling in the etiopathogenesis of autoimmune and neurodegenerative diseases. Finally, we will explore how to translate the scientific evidence of CD200-CD200R interaction into possible clinical therapeutic strategies to tackle neuroinflammatory CNS diseases. This article is part of a Special Issue entitled: Microglia-Neuron interactions in health and disease - novel perspectives for translational research. (C) 2018 Published by Elsevier Ltd on behalf of IBRO.

引用

页码：118 / 136

页数：19