Epidemiology of childhood acute myeloid leukemia

被引：100
作者：
Puumala, Susan E. [1 ,2 ]
Ross, Julie A. [3 ,4 ]
Aplenc, Richard [5 ]
Spector, Logan G. [3 ,4 ]
机构：
[1] Sanford Res, Ctr Hlth Outcomes & Prevent Res, Sioux Falls, SD USA
[2] Univ S Dakota, Sanford Sch Med, Dept Pediat, Sioux Falls, SD USA
[3] Univ Minnesota, Dept Pediat, Div Pediat Epidemiol & Clin Res, Minneapolis, MN 55455 USA
[4] Univ Minnesota, Masonic Canc Ctr, Minneapolis, MN USA
[5] Childrens Hosp Philadelphia, Philadelphia, PA 19104 USA
来源：
PEDIATRIC BLOOD & CANCER | 2013年 / 60卷 / 05期
关键词：
acute myeloid leukemia; children; epidemiology; CHILDRENS-CANCER-GROUP; MATERNAL REPRODUCTIVE HISTORY; ACUTE NONLYMPHOCYTIC LEUKEMIA; DNA TOPOISOMERASE-II; DIAGNOSTIC X-RAYS; INFANT LEUKEMIA; BIRTH-WEIGHT; ALCOHOL-CONSUMPTION; ONCOLOGY-GROUP; PARENTAL SMOKING;
D O I：
10.1002/pbc.24464
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Although leukemia is the most common childhood cancer diagnosis, the subtype, acute myeloid leukemia (AML), is less common and fewer etiologic studies exist. This review summarizes the major risk factors for AML. We searched the literature using PubMed for articles on childhood AML and reviewed 180 articles. While few risk factors are definitive, we identified several with consistent evidence of a possible effect. Thorough analysis of genetic and epigenetic factors is missing from this literature and methodological issues are unresolved. Future studies should more closely examine causal mechanisms, improve exposure measurement, and include analysis using genetic and epigenetic factors. Pediatr Blood Cancer 2013; 60: 728733. (c) 2013 Wiley Periodicals, Inc.
引用
收藏
页码：728 / 733
页数：6
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