INNOVATION TALENs: a widely applicable technology for targeted genome editing

被引：1111

作者：

Joung, J. Keith ^{[1
,2
]}

Sander, Jeffry D. ^{[1
,2
]}

机构：

[1] Massachusetts Gen Hosp, Ctr Computat & Integrat Biol, Mol Pathol Unit, Charlestown, MA 02129 USA

[2] Harvard Univ, Sch Med, Ctr Canc Res, Dept Pathol, Charlestown, MA 02129 USA

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2013年 / 14卷 / 01期

基金：

美国国家卫生研究院;

关键词：

ZINC-FINGER NUCLEASES; DOUBLE-STRAND BREAKS; GENE DISRUPTION; EFFECTOR NUCLEASES; EMBRYO MICROINJECTION; EFFICIENT GENERATION; DNA RECOGNITION; KNOCKOUT RATS; CELLS; MUTAGENESIS;

D O I：

10.1038/nrm3486

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Engineered nucleases enable the targeted alteration of nearly any gene in a wide range of cell types and organisms. The newly-developed transcription activator-like effector nucleases (TALENs) comprise a nonspecific DNA-cleaving nuclease fused to a DNA-binding domain that can be easily engineered so that TALENs can target essentially any sequence. The capability to quickly and efficiently alter genes using TALENs promises to have profound impacts on biological research and to yield potential therapeutic strategies for genetic diseases.

引用

页码：49 / 55

页数：7

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