Association studies of 5-HT2A and 5-HT2C serotonin receptor gene polymorphisms with prophylactic lithium response in bipolar patients

被引：0

作者：

Dmitrzak-Weglarz, M

Rybakowski, JK

Suwalska, A

Slopien, A

Czerski, PM

Leszczynska-Rodziewicz, A

Hauser, J

机构：

[1] Poznan Univ Med Sci, Lab Psychiat Genet, Dept Psychiat, PL-60572 Poznan, Poland

[2] Poznan Univ Med Sci, Dept Adult Psychiat, PL-60572 Poznan, Poland

[3] Poznan Univ Med Sci, Dept Child & Adolescent Psychiat, PL-60572 Poznan, Poland

来源：

PHARMACOLOGICAL REPORTS | 2005年 / 57卷 / 06期

关键词：

lithium prophylaxis; bipolar disorder; 5-HT2A; serotonin receptor 2A gene; 5-HT2C; serotonin receptor 2C gene; pharmacogenetics;

D O I：

暂无

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Lithium is one of the most commonly used drugs in the prophylaxis and treatment of bipolar disorder. The mechanisms of mood stabilization by lithium incorporate its effect. on serotonergic neurotransmission.' This paper investigates a relationship between response to lithium prophylaxis and polymorphisms in two genes: T102C of 5-HT2A receptor and G68C (Cys23Ser) of 5-HT2C serotonin receptor gene. Genotypes were estimated in 92 bipolar patients (39 males and 53 females) who have been taking lithium for at least 5 years. The patients were classified as excellent responders, partial responders and non-responders to lithium. The obtained results suggest that these polymorphisms may not be related to the degree of prophylactic lithium response.

引用

页码：761 / 765

页数：5

共 50 条

[1] ANALYSIS OF POLYMORPHISMS AT THE 5-HT2A AN 5-HT2C RECEPTOR GENES AND RESPONSE TO CLOZAPINE
ARRANZ, MJ
SODHI, M
BALL, D
SHAM, P
CURTIS, D
PRICE, J
ROBERTS, G
COLLIER, D
KERWIN, R
AMERICAN JOURNAL OF HUMAN GENETICS, 1995, 57 (04) : 1062 - 1062
[2] Biophysical validation of serotonin 5-HT2A and 5-HT2C receptor interaction
Felsing, Daniel E.
Anastasio, Noelle C.
Miszkiel, Joanna M.
Gilbertson, Scott R.
Allen, John A.
Cunningham, Kathryn A.
PLOS ONE, 2018, 13 (08):
[3] Epigenetic Regulation of Serotonin (5-HT) 5-HT2A:5-HT2C Receptor Balance in Maladaptive Impulsivity
Anastasio, Noelle C.
Miller, Aaron L.
Pyles, Richard B.
Moeller, F. Gerard
Ramesh, Divya
Sowers, Lawrence C.
Cunningham, Kathryn A.
NEUROPSYCHOPHARMACOLOGY, 2014, 39 : S330 - S330
[4] Association between clozapine response and allelic variation in the 5-HT2A and 5-HT2C receptor genes
Sodhi, MS
Arranz, MJ
Ball, DM
Roberts, GW
Price, J
Collier, DA
Kerwin, RW
SCHIZOPHRENIA RESEARCH, 1996, 18 (2-3) : IXB3 - IXB3
[5] 5-HT2A and 5-HT2C receptor polymorphisms and psychotic symptoms in Alzheimer's disease
Scordo, MG
Gunes, A
Dahl, ML
Arena, G
Cordici, E
Spina, E
EUROPEAN NEUROPSYCHOPHARMACOLOGY, 2005, 15 : S572 - S572
[6] Pleiotropic behavior of 5-HT2A and 5-HT2C receptor agonists
Berg, KA
Maayani, S
Goldfarb, J
Clarke, WP
ADVANCES IN SEROTONIN RECEPTOR RESEARCH: MOLECULAR BIOLOGY, SIGNAL TRANSDUCTION, AND THERAPEUTICS, 1998, 861 : 104 - 110
[7] Association studies of the 5-HT2A T102C and the 5-HT2C Cys23Ser receptor gene polymorphisms and suicidal behaviour
Pooley, EC
Hawton, K
Houston, K
Harrison, PJ
AMERICAN JOURNAL OF MEDICAL GENETICS, 2001, 105 (07): : 619 - 620
[8] 5-HT2A and 5-HT2C receptor stimulation are differentially involved in the cortical dopamine release in 5-HT2A and 5-HT2C genetic mutant mice
Huang, M.
Li, Z.
Prus, A. J.
Dai, J.
Meltzer, H. Y.
SCHIZOPHRENIA BULLETIN, 2007, 33 (02) : 317 - 318
[9] Colocalization of serotonin receptor subtypes 5-HT2A, 5-HT2C, and 5-HT6 with neuropeptides in rat striatum
Ward, RP
Dorsa, DM
JOURNAL OF COMPARATIVE NEUROLOGY, 1996, 370 (03) : 405 - 414
[10] Novel pyrimidoazepine analogs as serotonin 5-HT2A and 5-HT2C receptor ligands for the treatment of obesity
Yang, Ha Yun
Tae, Jinsung
Seo, Yong Wan
Kim, Yoon Jung
Im, Hye Yeon
Choi, Gil Don
Cho, Heeyeong
Park, Woo-Kyu
Kwon, Oh Seung
Cho, Yong Seo
Ko, Minkyung
Jang, HyunSeo
Lee, Jaeick
Choi, Kihang
Kim, Chan-Hwa
Lee, Jiyoun
Pae, Ae Nim
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2013, 63 : 558 - 569

← 1 2 3 4 5 →