Evolutionary Conservation of the PA-X Open Reading Frame in Segment 3 of Influenza A Virus

被引：96
作者：
Shi, Mang [2 ]
Jagger, Brett W. [1 ]
Wise, Helen M. [3 ]
Digard, Paul [3 ]
Holmes, Edward C. [2 ,4 ]
Taubenberger, Jeffery K. [1 ]
机构：
[1] NIAID, Viral Pathogenesis & Evolut Sect, Infect Dis Lab, NIH, Bethesda, MD 20892 USA
[2] Penn State Univ, Ctr Infect Dis Dynam, Dept Biol, University Pk, PA 16802 USA
[3] Univ Edinburgh, Roslin Inst, Edinburgh EH8 9YL, Midlothian, Scotland
[4] NIH, Fogarty Int Ctr, Bethesda, MD 20892 USA
来源：
JOURNAL OF VIROLOGY | 2012年 / 86卷 / 22期
基金：
英国生物技术与生命科学研究理事会; 英国医学研究理事会;
关键词：
CRYSTAL-STRUCTURE; ENDONUCLEASE;
D O I：
10.1128/JVI.01677-12
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
PA-X is a fusion protein of influenza A virus encoded in part from a +1 frameshifted X open reading frame (X-ORF) in segment 3. We show that the X-ORFs of diverse influenza A viruses can be divided into two groups that differ in selection pressure and likely function, reflected in the presence of an internal stop codon and a change in synonymous diversity. Notably, truncated forms of PA-X evolved convergently in swine and dogs, suggesting a strong species-specific effect.
引用
收藏
页码：12411 / 12413
页数：3
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