Evolutionary Conservation of the PA-X Open Reading Frame in Segment 3 of Influenza A Virus

被引：96

作者：

Shi, Mang ^{[2
]}

Jagger, Brett W. ^{[1
]}

Wise, Helen M. ^{[3
]}

Digard, Paul ^{[3
]}

Holmes, Edward C. ^{[2
,4
]}

Taubenberger, Jeffery K. ^{[1
]}

机构：

[1] NIAID, Viral Pathogenesis & Evolut Sect, Infect Dis Lab, NIH, Bethesda, MD 20892 USA

[2] Penn State Univ, Ctr Infect Dis Dynam, Dept Biol, University Pk, PA 16802 USA

[3] Univ Edinburgh, Roslin Inst, Edinburgh EH8 9YL, Midlothian, Scotland

[4] NIH, Fogarty Int Ctr, Bethesda, MD 20892 USA

来源：

JOURNAL OF VIROLOGY | 2012年 / 86卷 / 22期

基金：

英国医学研究理事会; 英国生物技术与生命科学研究理事会;

关键词：

CRYSTAL-STRUCTURE; ENDONUCLEASE;

D O I：

10.1128/JVI.01677-12

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

PA-X is a fusion protein of influenza A virus encoded in part from a +1 frameshifted X open reading frame (X-ORF) in segment 3. We show that the X-ORFs of diverse influenza A viruses can be divided into two groups that differ in selection pressure and likely function, reflected in the presence of an internal stop codon and a change in synonymous diversity. Notably, truncated forms of PA-X evolved convergently in swine and dogs, suggesting a strong species-specific effect.

引用

页码：12411 / 12413

页数：3

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