Bioactive aldehyde-modified phosphatidylethanolamines

被引：21

作者：

Guo, Lilu ^{[1
]}

Davies, Sean S. ^{[1
]}

机构：

[1] Vanderbilt Univ, Dept Pharmacol, Div Clin Pharmacol, Nashville, TN 37232 USA

来源：

BIOCHIMIE | 2013年 / 95卷 / 01期

关键词：

Lipid peroxidation; Aldehyde-modified phosphatidylethanolamine; Proinflammatory effects; LOW-DENSITY-LIPOPROTEIN; LIPID-PEROXIDATION; OXIDATIVE STRESS; P-HYDROXYPHENYLACETALDEHYDE; COVALENT MODIFICATION; PESTICIDE EXPOSURE; MASS-SPECTROMETRY; PRODUCTS; ADDUCTS; IDENTIFICATION;

D O I：

10.1016/j.biochi.2012.07.010

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Lipid peroxidation generates a variety of lipid aldehydes, which have been recognized to modify protein and DNA, causing inflammation and cancer. However, recent studies demonstrate that phosphatidylethanolamine (PE) is a major target for these aldehydes, forming aldehyde-modified PEs (al-PEs) as a novel family of mediators for inflammation. This review summarizes our current understanding of these al-PEs, including formation, detection, structural characterization, physiological relevance and mechanism of action. (C) 2012 Elsevier Masson SAS. All rights reserved.

引用

页码：74 / 78

页数：5

共 49 条

[1] Pyridoxamine: An extremely potent scavenger of 1,4-dicarbonyls [J].

Amarnath, V ;

Amarnath, K ;

Davies, S ;

Roberts, LJ .

CHEMICAL RESEARCH IN TOXICOLOGY, 2004, 17 (03) :410-415

[2] Evidence for in situ ethanolamine phospholipid adducts with hydroxy-alkenals [J].

Bacot, Sandrine ;

Bernoud-Hubac, Nathalie ;

Chantegrel, Bernard ;

Deshayes, Christian ;

Doutheau, Alain ;

Ponsin, Gabriel ;

Lagarde, Michel ;

Guichardant, Michel .

JOURNAL OF LIPID RESEARCH, 2007, 48 (04) :816-825

[3]

Bakulski K.M., 2012, CURR ALZHEIMER RES

[4] IDENTIFICATION OF 4-HYDROXYNONEAL AS A CYTO-TOXIC PRODUCT ORIGINATING FROM THE PEROXIDATION OF LIVER MICROSOMAL LIPIDS [J].

BENEDETTI, A ;

COMPORTI, M ;

ESTERBAUER, H .

BIOCHIMICA ET BIOPHYSICA ACTA, 1980, 620 (02) :281-296

[5] Covalent binding of isoketals to ethanolamine phospholipids [J].

Bernoud-Hubac, N ;

Fay, LB ;

Armarnath, V ;

Guichardant, M ;

Bacot, S ;

Davies, SS ;

Roberts, LJ ;

Lagarde, M .

FREE RADICAL BIOLOGY AND MEDICINE, 2004, 37 (10) :1604-1611

[6] Characterization of acrolein-glycerophosphoethanolamine lipid adducts using electrospray mass spectrometry [J].

Berry, Karin A. Zemski ;

Murphy, Robert C. .

CHEMICAL RESEARCH IN TOXICOLOGY, 2007, 20 (09) :1342-1351

[7] Chronic systemic pesticide exposure reproduces features of Parkinson's disease [J].

Betarbet, R ;

Sherer, TB ;

MacKenzie, G ;

Garcia-Osuna, M ;

Panov, AV ;

Greenamyre, JT .

NATURE NEUROSCIENCE, 2000, 3 (12) :1301-1306

[8] Crosslinking of aminophospholipids in cellular membranes of lens by oxidative stress in vitro [J].

Bhuyan, DK ;

Master, RWP ;

Bhuyan, KC .

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, 1996, 1285 (01) :21-28

[9] MOLECULAR MECHANISMS OF CATARACTOGENESIS .4. EVIDENCE OF PHOSPHOLIPID-MALONDIALDEHYDE ADDUCT IN HUMAN SENILE CATARACT [J].

BHUYAN, KC ;

MASTER, RWP ;

COLES, RS ;

BHUYAN, DK .

MECHANISMS OF AGEING AND DEVELOPMENT, 1986, 34 (03) :289-296

[10] Identification and quantification of phosphatidylethanolamine-derived glucosylamines and aminoketoses from human erythrocytes - Influence of glycation products on lipid peroxidation [J].

Breitling-Utzmann, CM ;

Unger, A ;

Friedl, DA ;

Lederer, MO .

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 2001, 391 (02) :245-254

← 1 2 3 4 5 →