Acute Cytomegalovirus Infection Is Associated with Increased Frequencies of Activated and Apoptosis-Vulnerable T Cells in HIV-1-Infected Infants

被引：28

作者：

Slyker, Jennifer A. ^{[1
,2
]}

Rowland-Jones, Sarah L. ^{[2
]}

Dong, Tao ^{[2
]}

Reilly, Marie ^{[3
]}

Richardson, Barbra ^{[4
]}

Emery, Vincent C. ^{[5
]}

Atzberger, Ann ^{[6
]}

Mbori-Ngacha, Dorothy ^{[7
]}

Lohman-Payne, Barbara L. ^{[1
,7
,8
]}

John-Stewart, Grace C. ^{[1
,8
,9
,10
]}

机构：

[1] Univ Washington, Dept Global Hlth, Seattle, WA 98195 USA

[2] Univ Oxford, MRC Human Immunol Unit, Weatherall Inst Mol Med, Oxford, England

[3] Karolinska Inst, Stockholm, Sweden

[4] Univ Washington, Dept Biostat, Seattle, WA 98195 USA

[5] UCL, Ctr Virol, Dept Infect, Sch Biomed & Life Sci, London, England

[6] Univ Oxford, Mol Haematol Unit, Weatherall Inst Mol Med, Oxford, England

[7] Univ Nairobi, Dept Paediat & Child Hlth, Nairobi, Kenya

[8] Univ Washington, Dept Med, Seattle, WA USA

[9] Univ Washington, Dept Pediat, Seattle, WA 98195 USA

[10] Univ Washington, Dept Epidemiol, Seattle, WA 98195 USA

来源：

JOURNAL OF VIROLOGY | 2012年 / 86卷 / 20期

关键词：

IMMUNODEFICIENCY-VIRUS TYPE-1; DISEASE PROGRESSION; VIRAL LOAD; ANTIRETROVIRAL THERAPY; ALLOGRAFT RECIPIENTS; 1-INFECTED CHILDREN; CMV INFECTION; HIV-INFECTION; LYMPHOCYTE; MORTALITY;

D O I：

10.1128/JVI.00790-12

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Cytomegalovirus (CMV) coinfection is associated with infant HIV-1 disease progression and mortality. In a cohort of Kenyan HIV-infected infants, the frequencies of activated (CD38(+) HLA-DR+) and apoptosis-vulnerable (CD95(+) Bcl-2(-)) CD4(+) and CD8(+) T cells increased substantially during acute CMV infection. The frequency of activated CD4(+) T cells was strongly associated with both concurrent CMV coinfection (P = 0.001) and HIV-1 viral load (P = 0.05). The frequency of apoptosis-vulnerable cells was also associated with CMV coinfection in the CD4 (P = 0.02) and CD8 (P < 0.001) T cell subsets. Similar observations were made in HIV-exposed uninfected infants. CMV-induced increases in T cell activation and apoptosis may contribute to the rapid disease progression in coinfected infants.

引用

页码：11373 / 11379

页数：7

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