Extramammary Paget's disease of the vulva: An annotated review of the current literature

被引:50
作者
Delport, Elsie Sophia [1 ]
机构
[1] Wesley Hosp, Intens Care Unit, Brisbane, Qld, Australia
关键词
clinical picture; extramammary; histogenesis; Imiquimod; lymph node biopsy; Paget's disease; pathology; treatment; vulva; MOHS MICROGRAPHIC SURGERY; IMIQUIMOD 5-PERCENT CREAM; PARK CANCER INSTITUTE; PHOTODYNAMIC THERAPY; TOPICAL IMIQUIMOD; IN-SITU; COMBINATION CHEMOTHERAPY; PROGNOSTIC-FACTORS; SURGICAL-TREATMENT; SKIN-DISEASE;
D O I
10.1111/j.1440-0960.2012.00898.x
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
Extramammary Paget's disease is a rare and unusual neoplastic entity that presents mainly on apocrine gland-bearing skin. The vulva is the most common site of involvement but any area of the anogenital skin can be affected. Due to its rarity, variable clinical course and deceptive histological appearance it has a high misdiagnosis rate and both gynaecologists and dermatologists have limited experience in its management. The significance of the disease lies in its association with underlying malignancy as well as its inherent ability to invade the dermis and metastasise. The management is notoriously complicated and recurrence rates are high despite aggressive surgeries. Several alternative modalities are being explored, with results that are often variable and unpredictable. This review summarises the histopathological, clinical and therapeutic features of extramammary Paget's disease of the vulva reported in recent years.
引用
收藏
页码:9 / 21
页数:13
相关论文
共 124 条
[1]   THE MEANING OF SURGICAL MARGINS [J].
ABIDE, JM ;
NAHAI, F ;
BENNETT, RG .
PLASTIC AND RECONSTRUCTIVE SURGERY, 1984, 73 (03) :492-496
[2]   MAMMARY AND EXTRAMAMMARY PAGET'S DISEASE: A STUDY OF 14 CASES AND THE ASSOCIATED THERAPEUTIC DIFFICULTIES [J].
Andretta Tanaka, Vanessa D. ;
Sanches, Jose Antonio ;
Torezan, Luis ;
Niwa, Ane Beatriz ;
Neto, Cyro Festa .
CLINICS, 2009, 64 (06) :599-606
[3]   Clinical treatment of vulvar Paget's disease: a case report [J].
Anton, Cristina ;
da Costa Luiz, Arthur Vicentini ;
Carvalho, Filomena Marino ;
Baracat, Edmund Chada ;
Carvalho, Jesus Paula .
CLINICS, 2011, 66 (06) :1109-1111
[4]  
Appert DL, 2005, DERMATOL SURG, V31, P1417
[5]   METASTATIC EXTRAMAMMARY PAGETS-DISEASE - DRAMATIC RESPONSE TO COMBINED MODALITY TREATMENT [J].
BALDUCCI, L ;
ATHAR, M ;
SMITH, GF ;
KHANSUR, T ;
MCKENZIE, D ;
CRAWFORD, ED .
JOURNAL OF SURGICAL ONCOLOGY, 1988, 38 (01) :38-44
[6]   EXTRAMAMMARY PAGETS-DISEASE - AN ANNOTATED REVIEW [J].
BALDUCCI, L ;
CRAWFORD, ED ;
SMITH, GF ;
LAMBUTH, B ;
MCGEHEE, R ;
HARDY, C .
CANCER INVESTIGATION, 1988, 6 (03) :293-303
[7]  
Battles OE, 1997, AM J CLIN PATHOL, V108, P6
[8]  
Becker-Wegerich PM, 1998, BRIT J DERMATOL, V138, P169
[9]   Vulvar toker cells: The long-awaited missing link - A proposal for an origin-based histogenetic classification of extramammary Paget disease [J].
Belousova, Irena E. ;
Kazakov, Dmitry V. ;
Michal, Michal ;
Suster, Saul .
AMERICAN JOURNAL OF DERMATOPATHOLOGY, 2006, 28 (01) :84-86
[10]  
Bertozzi Serena, 2009, Gynaekologisch-Geburtshilfliche Rundschau, V49, P326, DOI 10.1159/000301110