Candida albicans infection inhibits macrophage cell division and proliferation

被引：19

作者：

Lewis, Leanne E. ^{[1
]}

Bain, Judith M. ^{[1
]}

Lowes, Christina ^{[1
]}

Gow, Neil A. R. ^{[2
]}

Erwig, Lars-Peter ^{[1
,2
]}

机构：

[1] Univ Aberdeen, Div Appl Med, Aberdeen AB25 2ZD, Scotland

[2] Univ Aberdeen, Aberdeen Fungal Grp, Aberdeen AB25 2ZD, Scotland

来源：

FUNGAL GENETICS AND BIOLOGY | 2012年 / 49卷 / 09期

基金：

英国惠康基金;

关键词：

Candida albicans; Macrophage; Phagocytosis; Mitosis; Innate immunology; MURINE MACROPHAGES; ESCAPE;

D O I：

10.1016/j.fgb.2012.05.007

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The pathogenicity of the opportunistic human fungal pathogen Candida albicans depends on its ability to inhibit effective destruction by host phagocytes. Using live cell video microscopy, we show here for the first time that C albicans inhibits cell division in macrophages undergoing mitosis. Inhibition of macrophage cell division is dependent on the ability of C. albicans to form hyphae, as it is rarely observed following phagocytosis of UV-killed or morphogenesis-defective mutant Candida. Interestingly, failed cell division following phagocytosis of hyphal C albicans is surprisingly common, and leads to the formation of large multinuclear macrophages. This raises question as to whether inhibition of macrophage cell division is another virulence attribute of C. albicans or enables host macrophages to contain the pathogen. (C) 2012 Elsevier Inc. All rights reserved.

引用

页码：679 / 680

页数：2

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