Convenient synthesis of 3-(1-carboxyalkyl)pyrido[2,3-d] pyrimidine-2,4-diones.

被引：0
作者：
Saoud, M
Benabdelouahab, FB
El Guemmout, F
Romerosa, AM
机构：
[1] Univ Abdelmalek Essaadi, Fac Sci Tetouan, Tetouan, Morocco
[2] Univ Almeria, Fac Ciencias, Area Quim Inorgan, Almeria 04071, Spain
来源：
HETEROCYCLIC COMMUNICATIONS | 2001年 / 7卷 / 05期
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中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Cheap and safety synthetic route to obtain 3-(1-carboxyalkyl)pyrido[2.3-d]pyrimidinediones (carboxyalkyl = -CHRCO2H; R = H, 7; CH2, 8; CH2Ph, 9; Ph. 10; CH2(C3H3N2, 11; (CH2)(2)CO2H, 12; CH2CO2H, 13) starting from 2.3-pyridinedicarboxylic acid, 1, is described. A process scheme consistent with empirical observations is proposed.
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页码：439 / 444
页数：6
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