Hollow-core photonic crystal fiber probe for remote fluorescence sensing with single molecule sensitivity

被引：25
作者：
Ghenuche, Petru [1 ]
Rigneault, Herve [1 ]
Wenger, Jerome [1 ]
机构：
[1] Aix Marseille Univ, Ecole Cent Marseille, CNRS, Inst Fresnel, F-13013 Marseille, France
来源：
OPTICS EXPRESS | 2012年 / 20卷 / 27期
基金：
欧洲研究理事会;
关键词：
CORRELATION SPECTROSCOPY; OPTICAL-FIBER; RAMAN-SPECTROSCOPY; NANOJETS; BACKSCATTERING; NANOPARTICLES; MICROSPHERES; SENSOR; LIGHT;
D O I：
10.1364/OE.20.028379
中图分类号：
O43 [光学];
学科分类号：
070207 ; 0803 ;
摘要：
Current optical fiber probes for fluorescence spectroscopy struggle with large luminescence background and low detection sensitivities that challenge the detection of fluorescent molecules at sub-micromolar concentration. Here we report the demonstration of a hollow-core photonic crystal fiber (HC-PCF) probe for remote fluorescence sensing with single molecule sensitivity down to nanomolar concentrations, where both the excitation and fluorescence beams are counter-propagating through the same fiber. A 20 mu m polystyrene microsphere is used to efficiently excite and collect the fluorescence from the sample solution thanks to a photonic nanojet effect. Compared to earlier work with silica fibers, the new HC-PCF-microsphere probe achieves a 200x improvement of the signal-to-noise ratio for a single molecule detection event, and a 1000x reduction of the minimum detectable concentration. The device is implemented with fluorescence correlation spectroscopy to distinguish between molecules of similar fluorescence spectra based on the analysis of their translational diffusion properties, and provides similar performance as conventional confocal microscopes. (C) 2012 Optical Society of America
引用
收藏
页码：28379 / 28387
页数：9
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