Exploring the pathogenesis of IIH: An inflammatory perspective

被引：79

作者：

Sinclair, Alexandra J. ^{[1
,2
]}

Ball, Alexandra K. ^{[2
]}

Burdon, Michael A.

Clarke, Carl E. ^{[2
]}

Stewart, Paul M. ^{[2
]}

Cumow, S. John

Rauz, Saaeha

机构：

[1] Univ Birmingham, Inst Biomed Res, Sch Immunol Infect & Inflammat, Acad Unit Ophthalmol,Coll Med & Dent Sci, Birmingham B15 2TT, W Midlands, England

[2] Univ Birmingham, Coll Med & Dent Sci, Sch Expt Med, Birmingham B15 2TT, W Midlands, England

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2008年 / 201卷

基金：

英国医学研究理事会;

关键词：

Idiopathic intracranial hypertension; Obesity; Chronic inflammation; 11 beta-hydroxysteroid dehydrogenase;

D O I：

10.1016/j.jneuroim.2008.06.029

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Idiopathic intracranial hypertension (IIH) is a common blinding condition amongst the young obese female population (20 per 100,000) characterised by elevated intracranial pressure (ICP). The aetiology of IIH is not known. In this review we explore the literature investigating the pathogenesis of IIH and suggest additional hypotheses. Chronic inflammation is emerging as an aetiological factor in the pathogenesis of obesity and we propose that this may be a feature of IIH. Obesity is also related to dysregulation of cortisol production by the pre-receptor enzyme, 11 beta-hydroxysteroid dehydrogenase, and we speculate that this may have a role in the pathogenesis of obesity and raised ICP seen in IIH. (c) 2008 Elsevier B.V. All rights reserved.

引用

页码：212 / 220

页数：9

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