A New Role for Lyn in the CLL Microenvironment

被引：3
作者：
Dong, Shuai [1 ]
Byrd, John C. [1 ,2 ,3 ,4 ]
机构：
[1] Ohio State Univ, Coll Pharm, Div Pharmaceut & Pharmaceut Chem, 500 W 12Th Ave, Columbus, OH 43210 USA
[2] Ohio State Univ, Dept Internal Med, Div Hematol, Columbus, OH 43210 USA
[3] Ohio State Univ, Ctr Comprehens Canc, Columbus, OH 43210 USA
[4] Ohio State Univ, Coll Pharm, Div Med Chem, 500 W 12Th Ave, Columbus, OH 43210 USA
来源：
CANCER CELL | 2016年 / 30卷 / 04期
关键词：
CHRONIC LYMPHOCYTIC-LEUKEMIA; AUTOIMMUNE-DISEASE; DEFICIENT MICE; B-CELLS;
D O I：
10.1016/j.ccell.2016.09.018
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The role of Lyn, both a positive and a negative regulator of B and myeloid cells, in chronic lymphocytic leukemia (CLL) has not been well characterized. In this issue of Cancer Cell, Nguyen et al. demonstrated that Lyn in macrophages rather than in CLL cells is critical for the malignancy.
引用
收藏
页码：511 / 512
页数：2
相关论文
共 10 条
[1]   Human chronic lymphocytic leukemia modeled in mouse by targeted TCL1 expression [J].
Bichi, R ;
Shinton, SA ;
Martin, ES ;
Koval, A ;
Calin, GA ;
Cesari, R ;
Russo, G ;
Hardy, RR ;
Croce, CM .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (10) :6955-6960
[2]   Idelalisib, an inhibitor of phosphatidylinositol 3-kinase p110δ, for relapsed/refractory chronic lymphocytic leukemia [J].
Brown, Jennifer R. ;
Byrd, John C. ;
Coutre, Steven E. ;
Benson, Don M. ;
Flinn, Ian W. ;
Wagner-Johnston, Nina D. ;
Spurgeon, Stephen E. ;
Kahl, Brad S. ;
Bello, Celeste ;
Webb, Heather K. ;
Johnson, Dave M. ;
Peterman, Sissy ;
Li, Daniel ;
Jahn, Thomas M. ;
Lannutti, Brian J. ;
Ulrich, Roger G. ;
Yu, Albert S. ;
Miller, Langdon L. ;
Furman, Richard R. .
BLOOD, 2014, 123 (22) :3390-3397
[3]   Nurture versus Nature: The Microenvironment in Chronic Lymphocytic Leukemia [J].
Burger, Jan A. .
HEMATOLOGY-AMERICAN SOCIETY OF HEMATOLOGY EDUCATION PROGRAM, 2011, :96-103
[4]   Targeting BTK with Ibrutinib in Relapsed Chronic Lymphocytic Leukemia [J].
Byrd, John C. ;
Furman, Richard R. ;
Coutre, Steven E. ;
Flinn, Ian W. ;
Burger, Jan A. ;
Blum, Kristie A. ;
Grant, Barbara ;
Sharman, Jeff P. ;
Coleman, Morton ;
Wierda, William G. ;
Jones, Jeffrey A. ;
Zhao, Weiqiang ;
Heerema, Nyla A. ;
Johnson, Amy J. ;
Sukbuntherng, Juthamas ;
Chang, Betty Y. ;
Clow, Fong ;
Hedrick, Eric ;
Buggy, Joseph J. ;
James, Danelle F. ;
O'Brien, Susan .
NEW ENGLAND JOURNAL OF MEDICINE, 2013, 369 (01) :32-42
[5]   Chronic lymphocytic leukemia B cells contain anomalous Lyn tyrosine kinase, a putative contribution to defective apoptosis [J].
Contri, A ;
Brunati, AM ;
Trentin, L ;
Cabrelle, A ;
Miorin, M ;
Cesaro, L ;
Pinna, LA ;
Zambello, R ;
Semenzato, G ;
Donella-Deana, A .
JOURNAL OF CLINICAL INVESTIGATION, 2005, 115 (02) :369-378
[6]   Gain- and loss-of-function Lyn mutant mice define a critical inhibitory role of Lyn in the myeloid lineage [J].
Harder, KW ;
Parsons, LM ;
Armes, J ;
Evans, N ;
Kountouri, N ;
Clark, R ;
Quilici, C ;
Grail, D ;
Hodgson, GS ;
Dunn, AR ;
Hibbs, ML .
IMMUNITY, 2001, 15 (04) :603-615
[7]   MULTIPLE DEFECTS IN THE IMMUNE-SYSTEM OF LYN-DEFICIENT MICE, CULMINATING IN AUTOIMMUNE-DISEASE [J].
HIBBS, ML ;
TARLINTON, DM ;
ARMES, J ;
GRAIL, D ;
HODGSON, G ;
MAGLITTO, R ;
STACKER, SA ;
DUNN, ARR .
CELL, 1995, 83 (02) :301-311
[8]  
Kil LP, 2013, AM J BLOOD RES, V3, P71
[9]   IMPAIRED PROLIFERATION OF PERIPHERAL B-CELLS AND INDICATION OF AUTOIMMUNE-DISEASE IN LYN-DEFICIENT MICE [J].
NISHIZUMI, H ;
TANIUCHI, I ;
YAMANASHI, Y ;
KITAMURA, D ;
ILIC, D ;
MORI, S ;
WATANABE, T ;
YAMAMOTO, T .
IMMUNITY, 1995, 3 (05) :549-560
[10]   LYN Kinase in the Tumor Microenvironment Is Essential for the Progression of Chronic Lymphocytic Leukemia [J].
Phuong-Hien Nguyen ;
Fedorchenko, Oleg ;
Rosen, Natascha ;
Koch, Maximilian ;
Barthel, Romy ;
Winarski, Tomasz ;
Florin, Alexandra ;
Wunderlich, F. Thomas ;
Reinart, Nina ;
Hallek, Michael .
CANCER CELL, 2016, 30 (04) :610-622
1