2,4-Disubstituted thiazoles as multitargated bioactive molecules

被引:49
作者
Arora, Preeti [1 ]
Narang, Rakesh [1 ]
Nayak, Surendra Kumar [1 ]
Singh, Sachin Kumar [1 ]
Judge, Vikramjeet [2 ]
机构
[1] Lovely Profess Univ, Sch Pharmaceut Sci, Dept Pharmaceut Chem, Phagwara 144401, Punjab, India
[2] Guru Jambheshwar Univ Sci & Technol, Dept Pharmaceut Sci, Hisar 125001, Haryana, India
关键词
Anticancer; Anti-inflammatory; Antimicrobial; 2,4-Disubstituted thiazoles; Drug targets; Heterocyclics; MGLU5 RECEPTOR ANTAGONIST; BIOLOGICAL EVALUATION; MYCOBACTERIUM-TUBERCULOSIS; ANTITUMOR-ACTIVITY; ANTIMICROBIAL ACTIVITY; PHARMACOLOGICAL EVALUATION; ANTIINFLAMMATORY AGENTS; ANTICONVULSANT ACTIVITY; DERIVATIVES SYNTHESIS; ANTIOXIDANT ACTIVITY;
D O I
10.1007/s00044-016-1610-2
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
Thiazoles are important heterocyclics exhibiting boundaryless biological activities, such as antibacterial, antifungal, anti-inflammatory, antitumor, antitubercular, antidiabetic, antiviral, and antioxidant. Substituents on a particular position of the thiazole ring affect the biological outcomes to a great extent. Therefore, researchers have synthesized compounds containing the thiazole ring with variable substituents as target structures, and evaluated their biological activities. The present review describes the biological importance of recently developed 2,4-disubstituted thiazole derivatives. Moreover, we have thrown light on various targets of 2,4-disubstituted thiazoles through which they induce biological effects, which will be helpful to those who are working on the design and structure-activity relationship of bioactive molecules.
引用
收藏
页码:1717 / 1743
页数:27
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