The role of melanocortins in body weight regulation: opportunities for the treatment of obesity

被引：62

作者：

MacNeil, DJ ^{[1
]}

Howard, AD ^{[1
]}

Guan, XM ^{[1
]}

Fong, TM ^{[1
]}

Nargund, RP ^{[1
]}

Bednarek, MA ^{[1
]}

Goulet, MT ^{[1
]}

Weinberg, DH ^{[1
]}

Strack, AM ^{[1
]}

Marsh, DJ ^{[1
]}

Chen, HY ^{[1
]}

Shen, CP ^{[1
]}

Chen, ARS ^{[1
]}

Rosenblum, CI ^{[1
]}

MacNeil, T ^{[1
]}

Tota, M ^{[1
]}

MacIntyre, ED ^{[1
]}

Van der Ploeg, LHT ^{[1
]}

机构：

[1] Merck Res Labs, Rahway, NJ 07065 USA

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 2002年 / 440卷 / 2-3期

关键词：

melanocortins; melanocortin receptor; neuropeptide; ACTH (adrenocorticotropic hormone); AgRP (agouti-related protein); POMC (proopiomelanocortin); energy homeostasis; obesity; sexual function;

D O I：

10.1016/S0014-2999(02)01425-5

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Five G-protein-coupled melanocortin receptors (MC1-MC5) are expressed in mammalian tissues. The melanocortin receptors support diverse physiological functions, including the regulation of hair color, adrenal function, energy homeostasis, feed efficiency, sebaceous gland lipid production and immune and sexual function. The melanocortins (adrenocorticotropic hormone (ACTH), alpha-melanocyte-stimulating hormone (alpha-MSH), beta-MSH and gamma-MSH) are agonist peptide ligands for the melanocortin receptors and these peptides are processed from the pre-prohormone proopiomelanocortin (POMC). Peptide antagonists for the melanocortin MC1, MC3 and MC4 receptors include agoutirelated protein (AgRP) and agouti. Diverse lines of evidence, including genetic and pharmacological data obtained in rodents and humans, support a role for the melanocortin MC3 and MC4 receptors in the regulation of energy homeostasis. Recent advances in the development of potent and selective peptide and non-peptide melanocortin receptor ligands are anticipated to help unravel the roles for the melanocortin receptors in humans and to accelerate the clinical use of small molecule melanocortin mimetics. (C) 2002 Elsevier Science B.V All rights reserved.

引用

页码：141 / 157

页数：17

共 153 条

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