Fungal Quorum-Sensing Molecules and Inhibitors with Potential Antifungal Activity: A Review

被引：91

作者：

Mehmood, Arshad ^{[1
]}

Liu, Guorong ^{[1
]}

Wang, Xin ^{[1
]}

Meng, Guannan ^{[1
]}

Wang, Chengtao ^{[1
]}

Liu, Ya ^{[2
]}

机构：

[1] BTBU, Beijing Adv Innovat Ctr Food Nutr & Human Hlth, Beijing Engn & Technol Res Ctr Food Addit, Beijing 100048, Peoples R China

[2] China Tobacco Yunnan Ind Co Ltd, R&D Ctr, Kunming 650202, Yunnan, Peoples R China

来源：

MOLECULES | 2019年 / 24卷 / 10期

基金：

中国国家自然科学基金; 北京市自然科学基金;

关键词：

quorum sensing; fungi; quorum-sensing molecules; quorum-sensing inhibitors; antifungal activity; UNSATURATED FATTY-ACIDS; CANDIDA-ALBICANS; SACCHAROMYCES-CEREVISIAE; TRANSCRIPTIONAL RESPONSE; DEBARYOMYCES-HANSENII; BIOACTIVE PROPERTIES; PENICILLIUM-PANEUM; ALCOHOL PRODUCTION; ARACHIDONIC-ACID; CELL BIOLOGY;

D O I：

10.3390/molecules24101950

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The theory of persisting independent and isolated regarding microorganisms is no longer accepted. To survive and reproduce they have developed several communication platforms within the cells which facilitates them to adapt the surrounding environmental changes. This cell-to-cell communication is termed as quorum sensing; it relies upon the cell density and can stimulate several traits of microbes including biofilm formation, competence, and virulence factors secretion. Initially, this sophisticated mode of communication was discovered in bacteria; later, it was also confirmed in eukaryotes (fungi). As a consequence, many quorum-sensing molecules and inhibitors have been identified and characterized in various fungal species. In this review article, we will primarily focus on fungal quorum-sensing molecules and the production of inhibitors from fungal species with potential applications for combating fungal infections.

引用

页数：18

共 128 条

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