Acid-base properties of 2-phenethyldithiocarbamoylacetic acid, an antitumor agent

被引：0
|
作者：
Novozhilova, N. E. [1 ]
Kutina, N. N. [1 ]
Petukhova, O. A. [1 ]
Kharitonov, Yu Ya [2 ]
机构：
[1] OOO Medbiofarm, Obninsk, Russia
[2] Sechenov First Moscow State Med Univ, Moscow, Russia
来源：
RUSSIAN JOURNAL OF PHYSICAL CHEMISTRY A | 2013年 / 87卷 / 07期
关键词：
2-phenethyldithiocarbamoylacetic acid; isothiocyanate; pH-metric titration; sodium hydroxide; acidity constant; hydrolysis constant;
D O I：
10.1134/S0036024413070248
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
The acid-base properties of the 2-phenethyldithiocarbamoylacetic acid (PET) substance belonging to the class of isothiocyanates and capable of inhibiting the development of tumors on many experimental models were studied. The acidity and hydrolysis constants of the PET substance in ethanol, acetone, aqueous ethanol, and aqueous acetone solutions were determined from the data of potentiometric (pH-metric) titration of ethanol and acetone solutions of PET with aqueous solidum hydroxide at room temperature.
引用
收藏
页码：1121 / 1123
页数：3
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