Acid-base properties of 2-phenethyldithiocarbamoylacetic acid, an antitumor agent

被引：0
|
作者：
Novozhilova, N. E. [1 ]
Kutina, N. N. [1 ]
Petukhova, O. A. [1 ]
Kharitonov, Yu Ya [2 ]
机构：
[1] OOO Medbiofarm, Obninsk, Russia
[2] Sechenov First Moscow State Med Univ, Moscow, Russia
来源：
RUSSIAN JOURNAL OF PHYSICAL CHEMISTRY A | 2013年 / 87卷 / 07期
关键词：
2-phenethyldithiocarbamoylacetic acid; isothiocyanate; pH-metric titration; sodium hydroxide; acidity constant; hydrolysis constant;
D O I：
10.1134/S0036024413070248
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
The acid-base properties of the 2-phenethyldithiocarbamoylacetic acid (PET) substance belonging to the class of isothiocyanates and capable of inhibiting the development of tumors on many experimental models were studied. The acidity and hydrolysis constants of the PET substance in ethanol, acetone, aqueous ethanol, and aqueous acetone solutions were determined from the data of potentiometric (pH-metric) titration of ethanol and acetone solutions of PET with aqueous solidum hydroxide at room temperature.
引用
收藏
页码：1121 / 1123
页数：3
相关论文
共 50 条
  • [1] Acid-base properties of 2-phenethyldithiocarbamoylacetic acid, an antitumor agent
    N. E. Novozhilova
    N. N. Kutina
    O. A. Petukhova
    Yu. Ya. Kharitonov
    Russian Journal of Physical Chemistry A, 2013, 87 : 1121 - 1123
  • [2] Comparison of Spectrophotometric and Titrimetric Methods for Assay of 2-Phenethyldithiocarbamoylacetic Acid, a Novel Anticancer Drug
    N. E. Novozhilova
    N. N. Kutina
    Yu. Ya. Kharitonov
    Pharmaceutical Chemistry Journal, 2015, 49 : 208 - 209
  • [3] Comparison of Spectrophotometric and Titrimetric Methods for Assay of 2-Phenethyldithiocarbamoylacetic Acid, a Novel Anticancer Drug
    Novozhilova, N. E.
    Kutina, N. N.
    Kharitonov, Yu. Ya.
    PHARMACEUTICAL CHEMISTRY JOURNAL, 2015, 49 (03) : 208 - 209
  • [4] On the acid-base properties of humic acid in soil
    Cooke, James D.
    Hamilton-Taylor, John
    Tipping, Edward
    ENVIRONMENTAL SCIENCE & TECHNOLOGY, 2007, 41 (02) : 465 - 470
  • [5] Acid-base properties of amoxycillin
    Alekseev, VG
    Demskaya, EV
    Milashs, EA
    Igolkin, VV
    RUSSIAN JOURNAL OF GENERAL CHEMISTRY, 2005, 75 (07) : 1147 - 1150
  • [6] Acid-Base Properties of Amoxycillin
    V. G. Alekseev
    E. V. Demskaya
    E. A. Milashs
    V. V. Igolkin
    Russian Journal of General Chemistry, 2005, 75 : 1147 - 1150
  • [7] ACID-BASE PROPERTIES OF ACTH
    OSZTAS, E
    NOSZAL, B
    MAGYAR KEMIAI FOLYOIRAT, 1991, 97 (08): : 315 - 319
  • [8] Acid-Base Properties of Octaaryltetraazaporphyrins
    O. G. Khelevina
    S. V. Rumyantseva
    N. V. Chizhova
    P. A. Stuzhin
    I. S. Migalova
    Russian Journal of General Chemistry, 2003, 73 : 478 - 481
  • [9] ACID-BASE PROPERTIES OF ISONITROSOACETYLACETONE
    ROBOV, AM
    FEDOROVA, AV
    CHERKASHINA, VS
    BELYAEV, EY
    FEDOROV, VA
    ZHURNAL OBSHCHEI KHIMII, 1984, 54 (05): : 1173 - 1176
  • [10] ACID-BASE PROPERTIES OF OXIDES
    KIREEV, VA
    ZHURNAL FIZICHESKOI KHIMII, 1964, 38 (08): : 1881 - 1894
12345