Diterpenoids from Acanthopanax brachypus Harms

被引：6

作者：

Hu, Hao-Bin ^{[1
]}

Zheng, Xu-Dong ^{[1
]}

Hu, Huai-Sheng ^{[1
]}

Wu, Yun ^{[1
]}

机构：

[1] Longdong Univ, Coll Chem & Chem Engn, Qingyang 745000, Peoples R China

来源：

CHEMISTRY & BIODIVERSITY | 2013年 / 10卷 / 09期

关键词：

Acanthopanax brachypus; Diterpenoids; Noracanthopanin A; Acanthopanolide B; Cytotoxic activity; STEM BARK; SENTICOSUS;

D O I：

10.1002/cbdv.201200262

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Four diterpenoids, including two new ones, namely noracanthopanin A (1) and acanthopanolide B (2), and two known ones, ent-pimara-9(11),15-dien-19-oic acid (3) and ent-kaur-16-en-19-oic acid (4), were isolated from the stem bark of Acanthopanax brachypusHarms. Their structures were elucidated by physicochemical and spectroscopic analyses. Compound 1 and 2 exhibited moderate cytotoxicities against HO-8910 cells with IC50 values of 65.21 +/- 0.23 and 31.43 +/- 1.01g/ml, respectively, and 2 showed selective weak cytotoxicity against SMMC-7721 cells (IC50 89.67 +/- 2.54g/ml).

引用

页码：1623 / 1629

页数：7

共 17 条

[1]

[Anonymous], 2009, GANSU CHINESE MATERI, P59

[2]

[Anonymous], 1980, FLORA REIPUBLICAE PO, V54, P104

[3]

Bae, 2000, MED PLANTS KOREA, P361

[4] POTENTIAL ANTI-CANCER AGENTS .14. ISOLATION OF SPRUCEANOL AND MONTANIN FROM CUNURIA-SPRUCEANA (EUPHORBIACEAE) [J].

GUNASEKERA, SP ;

CORDELL, GA ;

FARNSWORTH, NR .

JOURNAL OF NATURAL PRODUCTS, 1979, 42 (06) :658-662

[5] Spirostanol and furostanol glycosides from the fresh tubers of Polianthes tuberosa [J].

Jin, JM ;

Zhang, YJ ;

Yang, CR .

JOURNAL OF NATURAL PRODUCTS, 2004, 67 (01) :5-9

[6] Kaurane-type diterpene glycoside from the stem bark of Acanthopanax trifoliatus [J].

Kiem, PV ;

Cai, XF ;

Van Minh, C ;

Lee, JJ ;

Kim, YH .

PLANTA MEDICA, 2004, 70 (03) :282-284

[7]

Kin Y. H., 1988, J NAT PRODUCTS, V51, P1080

[8]

[Liu Xiangqian 刘向前], 2004, [中草药, Chinese Traditional and Herbal Drugs], V35, P250

[9] Inhibition of protein tyrosine phosphatase 1B by diterpenoids isolated from Acanthopanax koreanum [J].

Na, MK ;

Oh, WK ;

Kim, YH ;

Cai, XF ;

Kim, SH ;

Kim, BY ;

Ahn, JS .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2006, 16 (11) :3061-3064

[10]

[倪娜 NI Na], 2006, [中草药, Chinese Traditional and Herbal Drugs], V37, P1895

← 1 2 →