For Wnt Signaling, Fucosylation of LRP6 Is a Bitter Pill

被引：0
|
作者：
Shah, Adnan Shami [1 ,2 ]
Sun, Hongyan [1 ,2 ]
Baskin, Jeremy M. [1 ,2 ]
机构：
[1] Cornell Univ, Dept Chem & Chem Biol, Ithaca, NY 14853 USA
[2] Cornell Univ, Weill Inst Cell & Mol Biol, Ithaca, NY 14853 USA
来源：
CELL CHEMICAL BIOLOGY | 2020年 / 27卷 / 09期
关键词：
D O I：
10.1016/j.chembiol.2020.08.003
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
In this issue of Cell Chemical Biology, Hong et al. (2020) use in situ chemoenzymatic labeling to discover that fucosylation of the Wnt co-receptor LRP6 induces its endocytosis and downregulates Wnt/beta-catenin signaling. Their findings reveal a glycosylation-based mechanism for regulating Wnt signaling that could be targeted in cancer.
引用
收藏
页码：1114 / 1116
页数：3
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