The Pharmaceutical Industry in 2017. An Analysis of FDA Drug Approvals from the Perspective of Molecules

被引：42

作者：

de la Torre, Beatriz G. ^{[1
]}

Albericio, Fernando ^{[2
,3
]}

机构：

[1] Univ KwaZulu Natal, Coll Hlth Sci, KRISP, ZA-4001 Durban, South Africa

[2] Univ KwaZulu Natal, Sch Chem & Phys, ZA-4001 Durban, South Africa

[3] Univ Barcelona, Dept Organ Chem, Networking Ctr Bioengn Biomat & Nanomed, CIBER BBN, E-08028 Barcelona, Spain

来源：

MOLECULES | 2018年 / 23卷 / 03期

基金：

新加坡国家研究基金会;

关键词：

drug discovery; API; peptide; biologics; small molecules; chemical entities;

D O I：

10.3390/molecules23030533

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

This is an analysis from a chemical point of view of the 46 drugs (34 New Chemical Entities and 12 Biologics) approved by the FDA during 2017. The drugs included in the 2017 "harvest" have been classified on the basis of their chemical structure: biologics (antibodies and proteins); peptides; amino acids and natural products; drug combinations; and small molecules.

引用

页数：8

共 8 条

[1] Strategies and challenges for the next generation of antibody drug conjugates [J].

Beck, Alain ;

Goetsch, Liliane ;

Dumontet, Charles ;

Corvaia, Nathalie .

NATURE REVIEWS DRUG DISCOVERY, 2017, 16 (05) :315-337

[2] The Pharmaceutical Industry in 2016. An Analysis of FDA Drug Approvals from a Perspective of the Molecule Type [J].

de la Torre, Beatriz G. ;

Albericio, Fernando .

MOLECULES, 2017, 22 (03)

[3]

Góngora-Benítez M, 2013, FUTURE MED CHEM, V5, P291, DOI [10.4155/FMC.13.5, 10.4155/fmc.13.5]

[4] New active series of growth hormone secretagogues [J].

Guerlavais, V ;

Boeglin, D ;

Mousseaux, D ;

Oiry, C ;

Heitz, A ;

Deghenghi, R ;

Locatelli, V ;

Torsello, A ;

Ghé, C ;

Catapano, F ;

Muccioli, G ;

Galleyrand, JC ;

Fehrentz, JA ;

Martinez, J .

JOURNAL OF MEDICINAL CHEMISTRY, 2003, 46 (07) :1191-1203

[5]

Jad YE, 2017, RSC DRUG DISCOV, V59, P518

[6]

Jarvis LM, 2018, CHEM ENG NEWS, V96, P26

[7]

Mullard A, 2018, NAT REV DRUG DISCOV, V17, P81, DOI 10.1038/nrd.2018.4

[8] Antibodies to watch in 2017 [J].

Reichert, Janice M. .

MABS, 2017, 9 (02) :167-181

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