The Molecular Basis of Malignant Pleural Mesothelioma

被引：42

作者：

Wadowski, Benjamin ^{[1
]}

De Rienzo, Assunta ^{[1
]}

Bueno, Raphael ^{[1
]}

机构：

[1] Harvard Med Sch, Brigham & Womens Hosp, Div Thorac Surg, 75 Francis St, Boston, MA 02115 USA

来源：

THORACIC SURGERY CLINICS | 2020年 / 30卷 / 04期

关键词：

Mesothelioma; Molecular; Genetic; Gene expression; Epigenetic; GENE-EXPRESSION RATIOS; TUMOR-SUPPRESSOR; BRCA1-ASSOCIATED PROTEIN-1; DEUBIQUITINASE BAP1; PREDICT SURVIVAL; POOR-PROGNOSIS; LUNG-CANCER; MUTATIONS; IDENTIFICATION; REVEALS;

D O I：

10.1016/j.thorsurg.2020.08.005

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

Malignant pleural mesothelioma (MPM) is a rare, aggressive malignancy of the pleural lining associated with asbestos exposure in greater than 80% of cases. It is characterized by molecular heterogeneity both between patients and within individual tumors. Next-generation sequencing technology and novel computational techniques have resulted in a greater understanding of the epigenetic, genetic, and transcriptomic hallmarks of MPM. This article reviews these features and discusses the implications of advances in MPM molecular biology in clinical practice.

引用

页码：383 / 393

页数：11

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