The neurological effects of ghrelin in brain diseases: Beyond metabolic functions

被引：45

作者：

Jiao, Qian ^{[1
,2
,3
]}

Du, Xixun ^{[1
,2
,3
]}

Li, Yong ^{[1
,2
,3
]}

Gong, Bing ^{[1
,2
,3
]}

Shi, Limin ^{[1
,2
,3
]}

Tang, Tingting ^{[1
,2
,3
]}

Jiang, Hong ^{[1
,2
,3
]}

机构：

[1] Qjngdao Univ, Shandong Prov Key Lab Pathogenesis & Prevent Neur, Coll Med, Dept Physiol, Qingdao, Peoples R China

[2] Qjngdao Univ, State Key Disciplines Physiol, Coll Med, Qingdao, Peoples R China

[3] Qingdao Univ, Shandong Prov Collaborat Innovat Ctr Neurodegener, Qingdao, Peoples R China

来源：

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS | 2017年 / 73卷

关键词：

Ghrelin; Neuronal survival; Apoptosis; Oxidative stress; Neurogenesis; Neurodegenerative disease; HORMONE SECRETAGOGUE RECEPTOR; DES-ACYL-GHRELIN; PHOSPHATIDYLINOSITOL-3-KINASE/AKT/GLYCOGEN SYNTHASE KINASE-3-BETA; SPINAL-CORD MOTONEURONS; PANCREATIC ALPHA-CELLS; O-ACYLTRANSFERASE GOAT; GROWTH-HORMONE; PARKINSONS-DISEASE; ALZHEIMERS-DISEASE; FOOD-INTAKE;

D O I：

10.1016/j.neubiorev.2016.12.010

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Ghrelin, a peptide released by the stomach that plays a major role in regulating energy metabolism, has recently been shown to have effects on neurobiological behaviors. Ghrelin enhances neuronal survival by reducing apoptosis, alleviating inflammation and oxidative stress, and accordingly improving mitochondrial function. Ghrelin also stimulates the proliferation, differentiation and migration of neural stem/progenitor cells (NS/PCs). Additionally, the ghrelin is benefit for the recovery of memory, mood and cognitive dysfunction after stroke or traumatic brain injury. Because of its neuroprotective and neurogenic roles, ghrelin may be used as a therapeutic agent in the brain to combat neurodegenerative disease. In this review, we highlight the pre-clinical evidence and the proposed mechanisms underlying the role of ghrelin in physiological and pathological brain function. (C) 2016 Elsevier Ltd. All rights reserved.

引用

页码：98 / 111

页数：14

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