Asymmetric synthesis of tetrahydroquinoline derivative, a building block of martinellines, via intramolecular allylic amination using 9-PBN

被引：17

作者：

Hamada, Y ^{[1
]}

Kunimune, Y ^{[1
]}

Hara, O ^{[1
]}

机构：

[1] Chiba Univ, Grad Sch Pharmaceut Sci, Inage Ku, Chiba 2638522, Japan

来源：

HETEROCYCLES | 2002年 / 56卷 / 1-2期

关键词：

Pd catalyzed cyclization; chiral monodentate phosphine; reagent controlled manner;

D O I：

10.3987/COM-01-S(K)46

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A tetrahydroquinoline derivative, a core structure of martinellines, was prepared through intramolecular allylic amination of the racemic precursor with a stereogenic center using 9-PBN and palladium. The reaction proceeded in a reagent-controlled manner based on the chiral phosphine to give two diastereomeric products with moderate enantioselectivities.

引用

页码：97 / 100

页数：4

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