Ebenfurans IV-VIII from Onobrychis ebenoides: Evidence that C-Prenylation is the Key Determinant of the Cytotoxicity of 3-Formyl-2-arylbenzofurans

被引：31

作者：

Halabalaki, Maria ^{[1
]}

Alexi, Xanthippi ^{[2
]}

Aligiannis, Necktarios ^{[1
]}

Alexis, Michael N. ^{[2
]}

Skaltsounis, Alexios-Leandros ^{[1
]}

机构：

[1] Univ Athens, Sch Pharm, Dept Pharmacognosy & Nat Prod Chem, GR-15771 Athens, Greece

[2] Natl Hellen Res Fdn, Inst Biol Res & Biotechnol, Mol Endocrinol Program, GR-11635 Athens, Greece

来源：

JOURNAL OF NATURAL PRODUCTS | 2008年 / 71卷 / 11期

关键词：

D O I：

10.1021/np800134h

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Phytochemical investigation of a methanol extract of Onobrychis ebenoides yielded five new 3-formyl-2-arylbenzofurans, namely, ebenfurans IV-VII (1-5), together with the known compounds ebenfurans I, II (6), and III (7). Only 1 and 7 exhibited growth inhibitory activity against MCF-7 and Ishikawa cells, suggesting that the prenyl moiety at position C-5 is the key determinant of the cytotoxic activity of this group of compounds.

引用

页码：1934 / 1937

页数：4

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