Parasites Dampen Dendritic Cell Activation to Ensure Their Survival

被引：2
作者：
von Stebut, Esther [1 ]
机构：
[1] Johannes Gutenberg Univ Mainz, Univ Med Ctr, Dept Dermatol, Mainz, Germany
来源：
TRENDS IN PARASITOLOGY | 2017年 / 33卷 / 02期
关键词：
LEISHMANIA-MAJOR INFECTION; IMMUNITY; MINCLE; SKIN;
D O I：
10.1016/j.pt.2016.12.001
中图分类号：
R38 [医学寄生虫学]; Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ; 100103 ;
摘要：
Dendritic cells (DCs) are critical for induction of protective immunity against Leishmania major. However, DC activation occurs only several weeks after parasite transmission. ParaSites synthesize a macrophage-inducible C-type lectin (Mincle) ligand. Engagement of Mincle by the parasite ligand dampens DC activation, thus delaying induction of interferon gamma-producing T cells responsible for parasite eradication.
引用
收藏
页码：78 / 80
页数：3
相关论文
共 50 条
  • [31] Survival of Chlamydia mutidarum within dendritic cells
    Rey-Ladino, Jose
    Jiang, Xiaozhou
    Gabel, Brent R.
    Shen, Caixia
    Brunham, Robert C.
    INFECTION AND IMMUNITY, 2007, 75 (08) : 3707 - 3714
  • [32] Dendritic cell subtypes and in vitro generation of dendritic cells
    Jacobs, B.
    Wuttke, M.
    Papewalis, C.
    Selssler, J.
    Schott, M.
    HORMONE AND METABOLIC RESEARCH, 2008, 40 (02) : 99 - 107
  • [33] Mettl3-mediated mRNA m6A methylation promotes dendritic cell activation
    Wang, Huamin
    Hu, Xiang
    Huang, Mingyan
    Liu, Juan
    Gu, Yan
    Ma, Lijia
    Zhou, Qi
    Cao, Xuetao
    NATURE COMMUNICATIONS, 2019, 10 (1)
  • [34] Suppression of the maturation and activation of the dendritic cell line DC2.4 by melanoma-derived factors
    Hargadon, Kristian M.
    Forrest, Osric A.
    Reddy, Pranay R.
    CELLULAR IMMUNOLOGY, 2012, 272 (02) : 275 - 282
  • [35] Rehmannia glutinosa polysaccharide functions as a mucosal adjuvant to induce dendritic cell activation in mediastinal lymph node
    Kwak, Minseok
    Yu, Kijin
    Lee, Peter Chang-Whan
    Jin, Jun-O
    INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2018, 120 : 1618 - 1623
  • [36] Dendritic cell-mediated survival signals in Eμ-Myc B-cell lymphoma depend on the transcription factor C/EBPβ
    Rehm, Armin
    Gaetjen, Marcel
    Gerlach, Kerstin
    Scholz, Florian
    Mensen, Angela
    Gloger, Marleen
    Heinig, Kristina
    Lamprecht, Bjoern
    Mathas, Stephan
    Begay, Valerie
    Leutz, Achim
    Lipp, Martin
    Doerken, Bernd
    Hoepken, Uta E.
    NATURE COMMUNICATIONS, 2014, 5
  • [37] Regulatory Dendritic Cells, T Cell Tolerance, and Dendritic Cell Therapy for Immunologic Disease
    Ness, Sara
    Lin, Shiming
    Gordon, John R.
    FRONTIERS IN IMMUNOLOGY, 2021, 12
  • [38] Role of heterogeneous cell population on modulation of dendritic cell phenotype and activation of CD8 T cells for use in cell-based immunotherapies
    Frizzell, Hannah
    Park, Jaehyung
    Lou, Natacha Comandante
    Woodrow, Kim A.
    CELLULAR IMMUNOLOGY, 2017, 311 : 54 - 62
  • [39] Inhibition of Dendritic Cell Maturation by the Tumor Microenvironment Correlates with the Survival of Colorectal Cancer Patients following Bevacizumab Treatment
    Michielsen, Adriana J.
    Noonan, Sinead
    Martin, Petra
    Tosetto, Miriam
    Marry, Joseph
    Biniecka, Monika
    Maguire, Aoife A.
    Hyland, John M.
    Sheahan, Kieran D.
    O'Donoghue, Diarmuid P.
    Mulcahy, Hugh E.
    Fennelly, David
    Ryan, Elizabeth J.
    O'Sullivan, Jacintha N.
    MOLECULAR CANCER THERAPEUTICS, 2012, 11 (08) : 1829 - 1837
  • [40] Increased plasmacytoid dendritic cell maturation and natural killer cell activation in HIV-1 exposed, uninfected intravenous drug users
    Tomescu, Costin
    Duh, Fuh-Mei
    Lanier, Michael A.
    Kapalko, Angela
    Mounzer, Karam C.
    Martin, Maureen P.
    Carrington, Mary
    Metzger, David S.
    Montaner, Luis J.
    AIDS, 2010, 24 (14) : 2151 - 2160
12345